| 产品详情 |
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| Product Name | JNK Inhibitor XVI, JNK-IN-8 |
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| Description | Purity ~97% (HPLC). A cell-permeable, selective, and irreversible type 2 inhibitor of c-Jun N-terminal kinases (JNK) (IC50=4.67nM, 18.7nM, 980pM for JNK1, JNK2, and JNK3, respectively). Forms a covalent adduct with the conserved cysteine residue (Cys116 in JNK1) and binds to JNK in an extended type 2 conformation. Blocks the phosphorylation of c-Jun in cells (EC50=486nM in HeLa cells; 338nM in A375 cells). Exhibits greater cellular specificity for JNK when compared to 40 other kinases screened using a cell-based assay. Shows weaker binding to KIT mutants (IC50=92nM for V559D and 56nM for T670I) and RIOK2 (120nM). Does not show any significant inhibitory activity against various other kinases, including ERK, p38, Akt, MSK, and RSK. Formula: C29H29N7O2 Molecular Weight: 507.6 Solubility: DMSO (100mg/ml, clear, yellowish solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JNK Inhibitor XVI, JNK-IN-8 ((E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217486 |
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| Order / More Info | JNK Inhibitor XVI, JNK-IN-8 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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