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| Product Name | Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL) |
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| Description | 1-213aa, Full Length. MW: 28.2 kDa. Purity >85% as determined by SDS-PAGE. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsiv |
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| Size | 0.05 mg (E-Coli), 0.05 mg (Baculovirus), 0.2 mg (Yeast), 0.05 mg (Mammalian-Cell), 0.1 mg (Baculovirus) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [von Hippel-Lindau disease tumor suppressor isoform 1; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau tumor suppressor; Protein G7; pVHL] |
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| Gene, Accession, CAS # | VHL, Gene ID: 7428, Accession: NP_000542.1 |
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| Catalog # | MBS962022 |
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| Order / More Info | Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL) from MYBIOSOURCE INC. |
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| Product Specific References | The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Pause A., Lee S., Worrel R., Chen D.Y.T., Burgess W.H., Linehan W.M., Klausner R.D. Proc. Natl. Acad. Sci. U.S.A. 94:2156-2161(1997) |
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