| 产品详情 |
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| Antigenic Specificity | CD60 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | fish, human |
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| Isotype | IgM |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | Flo (1:1), IHC, IHC-Fr, IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD60 Antibody LS-C43458. Recognizes the human CD60 antigen, a carbohydrate structure GD3 (Neu5Aca8Neu5Aca3Galbeta4GlcCer) modified by a terminal 9-0-acetylated disialosyl group (9-O-acetyl GD3). Does not recognize 7-O-acetyl GD3 or non-acetylated GD3. CD60 has been divided into 3 sub-types depending on the acetylation present. Non acetylated GD3 is termed CD60a and 7-O-acetyl GD3 termed CD60c. 9-O-acetyl GD3 as recognized by clone M-T6004 has been designated CD60b. CD60b is present on CD8+ve helper T cells, CD4+ve memory T cells and on activated B cells. Expression has also been reported on neuroectodermal cells and in breast carcinomas. CD60b is not expressed by naive T cells. GD3 has been described as a pro-apoptotic messenger targeting mitochondria in many lymphoid and myeloid cell types. Acetylation abrogates the pro-apoptotic activity of GD3 and CD60b protects tumor cells from apoptosis. |
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| Immunogen | Purified CD60 antigen from PBL; 9-0-acetyl-GD3 from buttermilk. |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | LS-C43458 |
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| Price | |
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| Order / More Info | CD60 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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