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| Product Name | Cardiotrophin 1, Recombinant, Human, His-Tag (CT-1) |
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| Description | Purity ~98% (RP-HPLC, SDS-PAGE). Cardiotrophin 1 (CT-1) is a 201aa member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT 1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT 1 activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes. CT 1 has also a neurotrophic function. CTF1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. Cardiotrophin 1 expression is au |
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| Size | 2ug, 5ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 299328 |
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| Order / More Info | Cardiotrophin 1, Recombinant, Human, His-Tag (CT-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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