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| Product Name | Soluble Fas Receptor, Recombinant, Human |
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| Description | Purity ~98% (SDS-PAGE and HPLC). Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. The full length Fas (receptor) is a 319aa type I transmembrane protein, which contains a 157aa extracellular domain, a 17aa transmembrane domain, and 145aa cytoplasmic domain. Recombinant human soluble Fas (sFas Receptor) is a 157aa polypeptide,17.6kD, corresponding to the TNFR homologous cysteine rich extracellular domain Fas. Source: Recombinant protein corresponding to human Soluble Fas Receptor, ex |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Soluble Fas Receptor, Recombinant, Human (ALPS1A, Apo-1 Antigen, Apoptosis-mediating Surface Antigen FAS, APT1, CD95, FAS1, FASLG Receptor, FASTM, Tumor Necrosis Factor Receptor Superfamily Member 6, TNFRSF6) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149655 |
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| Order / More Info | Soluble Fas Receptor, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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