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| Product Name | Dok, p62, Blocking Peptide, (Dok-1, Docking Protein, Downstream of Tyrosine Kinase, FRIP) |
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| Description | Purified 60-70%. Peptide corresponding to amino acids 425 to 439 of human p62dok (1). Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok represents a new family with very recently identified p56dok. Human DOK1 is a 481 amino acid protein. Docking proteins are substrates of tyrosine kinases and function in the recruitment and assembly of specific signal transduction molecules. Here we found that p62dok family members act as sub |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | D8080P |
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| Order / More Info | Dok, p62, Blocking Peptide, (Dok-1, Docking Protein, Downstream of Tyrosine Kinase, FRIP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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