| 产品详情 |
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| Antigenic Specificity | TRPA1 (Cytoplasmic domain) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | rat, mouse, human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | WB, IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human TRPA1 polyclonal antibody for WB, IHC. Transient receptor potential A1 (also known as Transient receptor potential ankyrin 1) is an excitatory ion channel on primary sensory nerves of the pain pathway. It is encoded by the TRPA1/ANKTM1 gene in human (Trpa1/Anktm1 in rat & mouse) and plays a critical role in pain associated with tissue injury, inflammation, and nerve lesions. TRPA1 is reported to colocalize with PAR2 and coexpress with TRPV1 (Transient receptor potential vanilloid 1) in rat dorsal root ganglion (DRG) neurons. Agonist-induced TRPA1 current is shown to be enhanced upon PAR2 cleavage/activation by proinflammatory trypsin & tryptase. TRPA1 activation, in turn, is reported to result in enhanced TRPV1 phosphorylation and activity in a calcium- and PKA-dependent manner. |
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| Immunogen | KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRPA1. |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 8989, UniProt: O75762 |
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| Catalog # | CABT-B1658 |
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| Price | |
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| Order / More Info | TRPA1 (Cytoplasmic domain) Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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| 产品资料 |
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