BMM 3D软骨剪切力测试分析系统， Shear Test on an Articular Cartilage Disc，关节软骨盘剪切试验系统

型号:MachOne多轴向机械力特性测试分析系统
联系人:李先生
联系电话:18618101725
品牌:加拿大BMM

BMM 3D软骨剪切力测试分析系统， Shear Test on an Articular Cartilage Disc，关节软骨盘剪切试验系统

（MachOne系统结构图：）

（使用MachOne Mechanical Tester - Compression, Shear and Torsion）

（MachOne Mechanical Tester - Shear Test on an Articular Cartilage Disc，关节软骨盘剪切试验）

背景：

MachOne系统的支架的底面上具有两个平行设置的承台，两个夹持装置分别设置在两个承台上。通过旋转调节阀就可以使其中的一个夹持装置升降，夹持装置产生纵向的相对位移，使两个夹持装置所夹持的腰椎间盘、软骨等样品产生剪切应力，从而应用于研究剪切应力与椎间盘退变之间的关系，应用于研究剪切应力与椎间盘、软骨等退变之间的关系，可以压缩、剪切、牵张、扭转。

剪切：

剪切试验可用于评估材料在平面剪切或扭转中的剪切模量G. 剪切模量表示当力沿平行于其运动的方向施加而其基部保持静止时材料的刚度。平衡剪切模量G被描述为剪切应变下的剪切应力。通常使用两种配置来确定剪切模量：平面剪切，其遵循水平轴（x或y轴），以及扭转剪切，其遵循旋转轴。在平面剪切的配置下，假设样品是完美的矩形棱柱，其中一个表面处于应力下并且其相对表面受到约束。在扭转剪切的配置下，假设样品是完美的圆柱体（惯性矩修正可以应用于其他形状），其顶部和底部表面完美地连接到两个压板（非滑动边界条件）。

机械刺激-剪切（MECHANICAL STIMULATION -SHEAR)

已经证明机械响应细胞构建体的剪切刺激对细胞活性具有重要影响，te别是对细胞外基质组分的产生。这种机械刺激通常在细胞培养期间进行。 BMM 的机械测试仪可以在干燥模式下安装在标准培养箱中。已针对此te定应用设计了封闭式测试室。在由与细胞培养相容的材料制成的腔室内直接控制湿度和气体水平。

（MachOne - 牙齿刷牙模拟器中牙膏的评估视频）

搭接剪切（LAP SHEAR）

与剥离测试一样，搭接剪切对于粘合剂的机械表征非常重要。在该测试配置中，通过粘合剂粘合在一起的两层材料被迫彼此滑动（没有剥离），从而在粘合剂层中引起剪切并终破裂。粘合剪切模量可通过多种测试方法表征。两种常用的方法是搭接（测试平面剪切以找到剪切模量和剪切强度）和对接（测试拉伸屈服，以找到剪切模量和弹塑性参数）。平面剪切试验意味着移动压板在与粘合相同的平面内移动。在这些配置下，假设样品是一个完美的矩形，其顶部和底部表面完美地连接到两个平面基板上（非滑动边界条件），尽管这种配置也可以记录力与滑移的位移数据物理粘附。

MachOne多轴机械特性测试分析系统

典型测试材料：

Articular Cartilage

Articular cartilage is the smooth white tissue that covers the ends of bones where they come together to form joints. Healthy cartilage in our joints makes it easier to move. It allows the bones to glide...

Skin (Wound Healing)

Wound healing is the process by which a tissue repairs itself after trauma. In the context of wound healing of skin, the goal is to regenerate the tissue in a manner that the original functional and structural...

Hydrogels

A hydrogel is constituted of a network of hydrophilic polymeric chains that can associate with large quantity of water without dissolving. Due to the nature of its composition, being mostly water, it has...

Articular Cartilage (Osteoarthitis)

Articular cartilage is the thin layer of tissue which lines the bony ends of all diarthrodial joints. Healthy cartilage in our joints makes it easier to move. It allows the bones to glide over each other...

Skin

Skin is a thin multilayered tissue covering the surface of the body of a person or animal. It is an anisotropic, non-linear and viscoelastic material. It is mainly composed of a network of collagen and...

Articular Cartilage (Repair)

Articular cartilage is the smooth white tissue that covers the ends of bones where they come together to form joints. Articular cartilage is vulnerable to traumatic injury and due to its poor vascularity,...

Bone

The mechanical properties of whole bones and bone tissue are as important as their morphological and structural aspects. Even if the mechanical behavior of bone can be described by some material properties,...

Meniscus

The meniscus is a fibrocartilaginous structure that serves as a shock absorber, lubricator and secondary stabilizer in the knee. It is shaped like two hemi-circular pieces with a triangular section attached...

Vascular (Vein and Artery)

The vascular system is the network of blood vessels including arteries, veins and capillaries that allow blood flow to and from the heart. The structure of the blood vessel walls is mainly composed of...

Articular Cartilage (Construct)

Articular cartilage is the smooth white tissue that covers the ends of bones where they come together to form joints. Articular cartilage is an avascular tissue and therefore, has low regenerative capacity....

Contact Lens

Contact lenses are thin lenses placed directly on the surface of the eye to correct visual defects. Mechanical testing of contact lenses is key to understanding their clinical quality and performance....

Rubber and Elastomer

Rubber and elastomer are viscoelastic materials used in various industries and applications. These materials can be tested in various mechanical configurations and through a wide range of experimental...

Disk (Intervertebral)

The intervertebral disc is a heterogeneous, cartilaginous structure that contributes to flexibility and load support in the spine. Biomechanically, the disc is subjected to different types of load and...

Teeth

Teeth are calcified, layered structures in the mouths of vertebrates. The main rigid constituents of the tooth are the enamel and dentin. The enamel is the hardest material in the body and dentin is harder...

Bone (Vertebral)

A vertebrae is an irregular bone of the spinal column. It has an outer shell called the cortical bone that is hard and strong with the inside made of soft and spongy cancellous bone. The vertebral body...

Articular Cartilage (TMJ)

Articular surfaces of the temporomandibular joints are covered by cartilage. Temporomandibular joints connect the lower jaw to the skull and regulates the movement of the jaw. Mechanical properties of...

Teeth (Brushing)

Tooth brushing is the most important behavior in oral hygiene, allowing the removal of dental plaque and aiding in the prevention of oral diseases such as gingivitis and dental caries. Tooth brushing studies...

Syringe

Syringe plunger can be more or less difficult to operate to deliver or aspire liquid or gel formulation in a controlled manner. A syringe is used to deliver or aspire liquid or gel formulation in a controlled...

Brain

Brain is a soft tissue contained in the skull of vertebrates. It is highly heteregenous because it contains both white and gray matter, which have different mechanical behaviors. Commonly used test methods...

Custom Material

...

Packaging Materials

Packaging materials are any material employed the packaging of products. They are used to protect its inside content for distribution, storage, sale and use. Mechanical properties of packaging materials...

Bone (Repair)

Bone has the ability to repair itself after a fracture. The healing process starts with the formation of a hematoma, then a fibrocartilage callus, bony callus and finally bone remodelling. Mechanical testing...

3D Printed Materials

3D printing, also known as additive manufacturing (AM), refers to processes used to synthesize a 3D object in which successive layers of material are formed under computer control. Objects can be of almost...

Teeth (Filling)

A dental filling is a restorative material used restore functionality to a tooth in the case of missing or damaged structure. The structural loss typically results from caries or external trauma. Mechanical...

Soft Tissue (Phantom)

Phantoms of soft tissues are easier to handle and eliminate the problem of sample-specific differences. They are widely used in surgical training from imaging technique (MRI, X-Ray, uCT, etc.) to the modelling...

Hydrogel (Beads)

...

Skin (Artificial)

Artificial skin refers to a collagen scaffold that induces regeneration of skin in mammals. The term was used in the late 1970s and early 1980s to describe a new treatment for massive burns. Mechanical...

Biocoating

Biocoating is the deposition of a thin layer of biocompatible material (e.g. hydrogel) over a non-biological surface. It can be implanted in the body or intended to be in contact with biological materials....

Plastic and Polymer (Rod)

Plastic and polymer are synthetic materials used in a wide range of applications. A wide variety of test configurations are compatible for the mechanical evaluation of material in the shape of a rod (straight...

Disk (Nucleus Pulposus)

The nucleus pulposus is the central part of an intervertebral disc. It is composed of a proteoglycan-water gel embedded in a randomly oriented network of fine collagen fiber and non-collagenous proteins....

Plastic and Polymer (Sheet)

Plastic and polymer are synthetic materials used in a wide range of applications. A wide variety of test configurations are applicable for the mechanical evaluation of material in the shape of a sheet....

Soft Tissue (Plantar)

Plantar soft tissues are located at the heel and ball of the foot and its primary role is to transfer forces to the skeleton by attenuating shock loads and vibrations. The mechanical properties of plantar...

Adhesives

...

Lung

Lungs are a pair of organs in the respiratory system. The mechanical behavior of lungs is a reflection of the gross tissue mechanics rather than a reflection of its individual components. The mechanical...

Surgical Suture Material

A surgical suture is a medical device used to hold body tissues together after an injury or surgery. Typically a suture thread is inserted through incision edges of a wound using a needle and is secured...

Ligament and Tendon

Ligaments and tendons are soft collagenous tissues. Ligaments connect bones together while tendons attach muscle to bone. Both ligaments and tendons are viscoelastic tissues. Together, tendons serve to...

Stents

...

Pharmaceutical Tablet

A pharmaceutical tablet is a solid compressed dosage form containing medicinal substances. In the pharmaceutical industry, a proper understanding of the mechanical properties of pharmaceutical tablet...

Hair

Hair is a fine thread, usually cylindrical, growth from the skin of humans or animals. Hair is a highly organized biomaterial composed mainly of keratin. At a molecular level, it is a very rigid structure...

Leather

Leather is a durable and flexible material created by tanning animal skin. Production of synthetic leathers has recently evolved and researchers have attempted to mimic the appearance and properties of...

Bone (Growth Plate)

Growth plates are located on the long bones of children and adolescents. Growth plates are avascular, aneural and consist of chondrocytes embedded in an extra-cellular matrix. Long bones grow longitudinally...

Ligament and Tendon (Repair)

Ligaments and tendons can rupture or be torn following high strains and sudden forces which is common in sports injuries. Tendon and ligament repair refers to the surgical healing of damaged or torn tissues....

Auricular Cartilage

Auricular cartilage is the cartilage of the outermost portion of the ear. It is a flexible connective tissue that has many applications particularly for facial reconstruction and rhinoplasty. Mechanical...

Disk (Anulus Fibrosus)

The annulus fibrosus is the outer layer of an intervertebral disc. It is subjected to a combination of compressive, tensile and shear stresses. The annulus fibrosus is a layered structure of a solid porous...

Lens (Eye)

The lens is a transparent, biconvex structure in the eye that, along with the cornea, helps refract light to be focused on the retina. The lens, by changing shape, has the function of modifying the focal...

Paper

Paper is a thin material produced by pressing together moist fibres and drying them into flexible sheets. Mechanical testing of paper could aid in the development of different paper varieties for technical,...

Bone (Filler Material)

Bone filler are used for the fixation of the majority of prostheses. The mechanical properties of bone filler are of particular interest since its failure leads to the failure of the prosthetic it holds...

Heart (Tissue Engineering)

The heart is the organ that pumps blood in the body. Cardiovascular disease includes a wide range of pathological conditions of the heart and vasculature. Thus, tissue engineering of cardiac tissue consists...

Needle

Needle is a fine slender piece of metal with a sharp point at one end. Mechanical properties of needles need to be assessed to precisely determine their specifications before their use in research or by...

Ligament and Tendon (Artificial)

Ligaments and tendons can tear and rupture following an injury. Repair is the first choice, but often a torn ligament or tendon heals poorly and must be replaced by artificial connective tissue or by a...

Textile

Textiles are made from both natural and manufactured fibres. They can be used for clothing, decoration and industrial applications. The mechanical properties of textile are assessed for different end-use...

Metallic Foil

Metallic foils are thin metal films used in a wide variety of applications. Mechanical properties of the foil depend on the material, dimensions and manufacturing process. Depending on the end-use application,...

Shell

A shell is a hard protective outer casing created by a mollusk or crustacean. These materials are lightweight but have very strong mechanical properties. The mechanical properties of the materials that...

Spider Silk

The tensile strength of spider silk is greater than the same weight of steel and has much greater elasticity. It is under investigation for potential applications in industry, including bullet-proof vests...

Prosthesis (Knee)

A knee prosthesis is an artificial device replacing a missing or injured part of the knee joint. Mechanical characterization of the knee prosthesis is crucial to assess the performance of the device including...

Prosthesis (Hip)

A hip prosthesis is an artificial device replacing a missing or injured part of the hip joint. Mechanical characterization of the hip prosthesis is crucial to assess the performance of the device including...

Soft tissues of the hand consist of skin, muscles and tendons, ligaments, nerves and blood vessels. Mechanical properties of these soft tissues are studied to learn about: their structural function in...

功能配置：

3D Normal Indentation Mapping

Mechanical indentation is a rapid and non-destructive assessment technique for biological tissues. Lately, BMM has improved and augmented this technique with both mapping capability and solving...

Tension

The tension test is a fundamental test configuration in the field of material characterization. By pulling on both ends, the goal here is to evaluate how a sample will react to applied loading or displacement...

Unconfined Compression

The unconfined compression test is by far the most popular mechanical testing configuration to measure the mechanical properties of cylindrical-shaped samples. Sample with other geometry can also be tested...

Indentation (Stiffness)

An indentation test is a very convenient way to measure the mechanical properties of a sample non-destructively. Unlike the unconfined compression test, where a sample needs to be harvested from the surface,...

Friction

Friction tests determine the ease of two surfaces to slide against each other when subjected to a contact force. Two main phenomenons are generally observed during these tests: static and kinetic friction....

Bending

Bending (or flexure) tests characterize the behavior of a slender sample (one dimension being a small fraction - a tenth - of the other two) with load applied perpendicular to its longitudinal axis. This...

Torsion

Torsion refers to the twisting of a sample due to an applied torque. Various applications requires materials to withstand torsional stress. It is thus important to test this configuration since material...

3D Thickness Mapping

Using a needle probe under the load cell, it is also possible to map the surface profile and the thickness of a layer of material over a stiffer substrate (e.g. the cartilage layer over a bone). This is...

Shear

Shear tests can be used to evaluate the shear modulus G of a material in planar shear or in torsion. The shear modulus represents the stiffness of a material when a force is applied in a direction parallel...

Simultaneous Compression and Torsion

Simultaneous compression and torsion can be used to determine the mechanical behaviour of specific use samples. This is required in the case where samples primarily undergo complex loading. To accurately...

Dynamic Mechanical Analysis

Dynamic mechanical properties can be assessed from the response of a material subjected to a periodic stimulus which can be applied axially (tension/compression), or in shear (planar or torsion). These...

Burst

This test is generally conducted to verify the mechanical resistance of packaging material or packaging seals to internal pressurization. Using BMM 's tester, this package pressurization is achieved...

Puncture

Penetration resistance testing involves the insertion of a probe (often a needle or a cone) into a material. Penetration resistance is an important end-use performance reference for thin flexible materials,...

Tack (Adhesive)

It is quite easy to tell when a material is tacky or sticky simply by touching it and feeling how difficult it is to remove it from our fingers. The tackiness is the ability of a material to adhere instantaneously...

Fracture

A complete or partial fracture is the natural conclusion of applying progressively higher amounts of stress to a material. This point could also be referred to as failure. A fracture test is used to find...

Tear

Components often fail in service due to the generation and propagation of a special type of rupture called a tear. The tear test configuration measures the resistance to tearing action on a sample. Resistance...

Push-Out Test

This test configuration is used to evaluate the mechanical stability of a cylindrical plug (bone filler, osteochondral , cartilage construct) after implantation. After sample preparation (normally...

Peeling (Stripping)

Peeling tests are employed to determine the strength of an adhesive bond between two materials. The peel strength is the average load per width unit required to separate that bond. Using its vertical axis,...

Impact

An impact test is used to quantify the resistance of a sample to high-rate loading. It is very useful in the safety study of product. For this test, an indenter is brought into contact with the sample...

Expression or Aspiration Force

Syringes are tested to quantify the force necessary to activate the plunger and express or aspirate fluid from, or to, the barrel (break-away force, glide force, etc). These forces depend on factors such...

Swelling and Contraction

Swelling and contraction of ionic gels can be induced by various factors such as pH, ionic concentration in the solution, ambient humidity, temperature, ongoing chemical reaction, etc. An easy way to study...

Lap Shear

Like the peel test, the lap shear is important for the mechanical characterization of adhesives. In this test configuration, two layers of material bonded together by an adhesive are forced to slide against...

Indentation (Hardness)

An indentation hardness test is a conventional method of measuring a solid material’s resistance to permanent damage after undergoing a compressive force. Using a very hard pointed indenter with known...

Confined Compression

Confined compression testing measures the capacity of a material to withstand axial compressive loads without expanding perpendicularly to the force. Confined compression tests are usually performed on...

Profilometry (3D)

Historically, profilometry was acknowledged as a graph of the surface height as the surface is moved relative to the contact profilometer's stylus (skating on the surface). This notion is changing with...

Profilometry (2D)

Historically, 2D profilometry was acknowledged as a graph of the surface height as the surface is moved relative to the contact profilometer's stylus (skating on the surface) over a line. This notion is...

Cantilever Bending

Cantilever bending (or flexure) tests characterize the behavior of a long sample (one dimension being a small fraction - a tenth - of the other two). In this particular case, an external load is applied...

Mechanical Stimulation (Compressive)

The compressive stimulation of mechanically-responsive cell construct has been demonstrated to have important effects on the cell's activity, in particular, over the production of extracellular matrix...

Mechanical Stimulation (Tension)

The mechanical stimulation in tension of mechanically-responsive cell constructs has been demonstrated to have important effects on the cell's activity, in particular, over the production of extracellular...

Mechanical Stimulation (Shear)

The shear stimulation of mechanically-responsive cell constructs has been demonstrated to have important effects on the cell's activity, in particular, over the production of extracellular matrix components....

Electromechanical Measurement

Certain materials will provide an electrical response to a mechanical stimulus, for example piezoelectric crystals. Certain biomaterials (hydrogels) and tissues (articular cartilage) also show electromechanical...

Positioning (Manual Tilt)

This test configuration is normally coupled with other test configuration(s) to improve measurement when the surface of the sample is not flat. For example, when a disk sample (or ) has nonparallel...

Positioning (XY Auto)

This tester configuration allows a precise control of the horizontal position (XY directions) of sample or sample holder. For each stage, the control is performed through the MachOne Motion software (same...

Positioning (X Auto)

This test configuration allows precise and automated control of the horizontal position (X direction) of a sample or sample holder. The control is performed through the MachOne Motion software (same as...

Positioning (Manual)

The ability to precisely move the sample across the horizontal plane (under the compression axis) is a great advantage in various experimental configurations. Ideally, one will go for the mechanically-controlled...

Camera Feed

...

Digital Image Correlation (DIC)

Digital image correlation (DIC) is an optical method that uses tracking and image registration techniques for accurate 2D and 3D measurements of changes in a sample during deformation. This is often used...

External Analog Sensors

It is possible to connect two external analog sensors (e.g. strain gauges (gages), electrodes, thermocouples, pressure sensors, etc.) to the tester electrical acquisition system. Acquisition of those channels...

研究案例：

Indentation Mapping on 36 Pig Skins for a Full Thickness Excision Model

Demonstration of of the tester's mapping capabilities on skin

Evaluation of the Mechanical Properties of Human Hair

Demontration of the tester's capabilities in tension and torsion in a low force experimental setup

Measuring the coefficient of friction between two cartilage surfaces in rotation

Demonstration of the tester capabilities in torsion

Characterization of the Mechanical Properties of Alginate Beads

Mechanical properties of alginate beads with diameters smaller than 1 mm are precisely measured

Characterization of the Mechanical Properties of Pharmaceutical Tablets

The swelling behavior and mechanical properties of pharmaceutical tablets were measured

Characterization of Electromechanical Properties of Connective Tissues - Part 1 - Articular Cartilage

Measure of the electrical potential generated in a connective tissues under deformation

Characterization of Electromechanical Properties of Connective Tissues - Part 2 - Meniscus

Measure of the electrical potential generated in connective tissues under deformation

In vitro Mechanical Stimulation of Articular Cartilage

In vitro mechanical stimulation of a cell construct inside an incubator

Characterization of a Sawbones tibial plateau replica

Demonstration of the 3D mechanical mapping capabilities of the multiaxial tester

Sequence of Mechanical Tests for Articular Cartilage at a Single Location

To minimize the number of required samples in cartilage repair studies

Identification of Early Degenerated (OA-like) Regions over Entire Articular Surfaces Using Indentation Mapping

Mechanical Testing of Entire Articular Surfaces Using Indentation Mapping

Indentation and Thickness Mapping on Rat Knee Articular Surfaces after Medial Meniscal Tear

Cryogenic 3D Printing of Super Soft Hydrogels

Using the MachOne to mechanically characterize super soft hydrogels

Innovative friction testing on contact lenses

An interesting study performed by a MachOne user

Relevance of the Spatial Distribution of Mechanical Properties of Articular Cartilage in Animal Studies

Assess the importance of proper selection of repair sites in cartilage repair studies

Cutting-edge synthetic brain developed for training budding brain surgeons

Using the MachOne to create a brain phantom

Testing of a brain sample

Evaluation of the capability of the tester to measure needle penetration forces in a brain specimen

Toothpaste testing

Application of a mechanical shear force to simulate teeth brushing

©BMM Inc.

相关文献案例：

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Hyaline-like cartilage repair can be occasionally elicited by bone marrow stimulation procedures however mainly in younger patients, indicating the need for further treatments to improve success rates in middle-aged patients. Traditional...
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https://mywbc.org/lectures/view/4119

Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritis Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CE2015 International Cartilage Repair Society, May 7-11 2015, Chicago, Illinois, USA. Podium presentation (ID: 23.2.9)

Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map...
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Lavoie-2015B-ICRS-Presentation.pdf

Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis Research Society International (OARSI), 2015 April 30, Seattle, WA, United States

Lavoie-2015c-ICRS-Abstract.pdf

Lavoie-2015E.pdf

Novel Technique to Map the Biomechanical Properties of Entire Mice Articular Surfaces Using IndentationSim S, Lavoie JF, Moreau A, Quenneville E, Garon M, and Buschmann MDOsteoarthritis and Cartilage, 22(1), 541. World Congress on Osteoarthritis, April 2014, Paris, France.

Purpose: An important measure of articular cartilage function in health and disease is its biomechanical properties. While much research has mouse models of osteoarthritis, the assessment of biomechanical properties in these small joints is...
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Sim-OARSI2014-Poster.pdf

Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Degenerated (Osteoarthritis-like) CartilageSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD7th World Congress on Biomechanics, 2014, Boston, MA, USA. Poster 2229

Introduction: A currently unsatisfied need in Arthritis and cartilage research is to assess the function of the entire articular cartilage surface both quantitatively and non-destructively. The objective of this study was to investigate the...
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Sim-2014e-WCB2014-Poster.pdf
Sim-2014d-ICoBT2014-Presentation.pdf

Indentation Method to Map Mechanical Properties of Articular Surface to Identify Degenerated RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD2014 Annual Meeting of the Biomedical Engineering Society, 2014, San Antonio, TX, USA. Podium presentation (ID: OP-Sat-3-4)

Introduction: The identification and quantitative grading of early degenerated regions over an entire articular surface remains a challenging quest. The objective of this study was to investigate the ability of a novel technique to...
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Sim-2014g-abstract.pdf
Sim-2014G (BMES2014 Presentation).pdf

Correlation of Non-destructive Electromechanical Probe () Assessment with Histological Ss and Mechanical Properties in Human Tibial PlateauSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 1228

The purpose of the study was to investigate if electromechanical properties of human tibial plateau correlate strongly with histological ss and with biomechanical properties as in human distal femurs (Sim et al., 2014). Six pairs of tibial...
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Sim-2015a-ORS2015-Poster.pdf

Relevance of the Spatial Distribution of Mechanical Properties of Articular Cartilage in Animal StudiesSim S, Hadjab I, Garon M, Quenneville E, and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 0359

Introduction: In cartilage regeneration and repair, mechanical testing of articular cartilage characterizes functional restoration of the repair site [1] and can detect early degeneration of articular cartilage [2]. However, the experimental...
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Sim-2015b-ORS2015-Poster.pdf
Sim-2015E-ICRS-Presentation.pdf

Evaluation of Entire Ovine Cartilage Repair Articular Surfaces: Mechanical and Electromechanical AssessmentSim S, Hadjab I, Garon M, Quenneville E, Hurtig MB, Buschmann MD and Hoemann CDTransactions of International Cartilage Repair Society (ICRS), Chicago, 2015, 7-11 May 2015, e-Poster: P87

Purpose: To demonstrate the ability of non-destructive electromechanical device and automated indentation technique in assessing the quality of cartilage in a sheep model of cartilage repair.

Methods: Ex vivo...
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Sim-2015F-ICRS-Abstract.pdf
Sim-2015F-ICRS-ePoster.pdf
Sim-2015F-ICRS-Poster.pdf

Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada

Introduction: Mechanical characterization of wound healing in skin samples mostly relies on uniaxial tensile rupture tests, which provide local information along the wound and are disruptive for samples (Chao et al., 2011). In this study, we...
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Sim-2015H-CCTC-Presentation.pdf
Sim-2015H-CCTC-Abstract-with-images.pdf

Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrand A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016

In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of...
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Sim-2016A-ORS2016-Poster.pdf

Cartilage Stiffness and Thickness Distributions Revealed by an Automated Indentation Technique in the Temporomandibular JointSim S, Matuska A, Garon M, Quenneville E, McFetridge P and Buschmann MDTMJ Bioengineering Conference - V, September 12-13, 2016, Barcelona, Spain

The purpose of this study was to evaluate the capability of an automated indentation technique to reveal the topographical variation of mechanical properties over the entire articular surface of the temporomandibular joint (TMJ), especially the...
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Sim-2016B (TMJ Bioengineering 2016 Abstract Proof).pdf
Sim-2016B (TMJ Bioengineering 2016 Presentation).pptx

Correlation of Non-destructive Electromechanical Probe () Assessment with Histological Ss, Biochemical Composition and Mechanical Properties in Human Knee JointsSim S, Chevrier A, Quenneville E, Garon M and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, Poster 0439, 2014

Introduction: Histological scoring, biochemical analyses and biomechanical testing (unconfined compression) are often seen as gold standard characterizations for articular cartilage but can present major drawbacks in the context of animal and...
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Sim-ORS2014a.pdf

Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Osteoarthritis-like RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, 2014, New Orleans, LA, USA, 2015, Poster #2015

Introduction: It is challenging to identify and grade degenerated regions of the entire articular surface both quantitatively and non-destructively. Therefore, the objective of this study was to investigate the ability of a novel technique to...
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Sim-ORS2014b.pdf

Age-dependence of the Pattern of Cartilage Electromechanical Properties in the Ovine Stifle JointSim S, Picard G, Quenneville E, Garon M and Buschmann MDTransactions of the 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, USA, 2013.

Introduction: The biochemical composition and mechanical/electromechanical properties of articular cartilage evolve during growth. The objective of this study was to examine the age-dependence in the distribution pattern of electromechanical...
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Sim-2013b-Poster.pdf

Streaming Potential-Based Arthroscopic Device Can Detect Changes Immediately Following Localized Impact in an Equine Impact Model of OsteoarthritisChangoor A, Quenneville E, Garon M, Hurtig MB and Buschmann MDOsteoarthritis and Cartilage, Vol. 17, Supplement 1, S53, World Congress on Osteoarthritis, September 2009, Montreal, Quebec, Canada. (2009)

Early Post-traumatic Osteoarthritis (PTOA) can be asymptomatic but represents a possible window of opportunity for therapeutic intervention before disease progression. Impact models are ideal for studying these strategies because the location and...
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Changoor-OARSI2009-poster.pdf

Comparison Between In Vitro and Simulated Arthroscopy Electromechanical Measurements of Human Articular Surfaces Using the Sim S, Becher C, Garon M, Quenneville E, Hurschler C and Buschmann MDInternational Cartilage Repair Society 2016 in Sorrento, Italy. Poster 132

Purpose: The output of the was originally streaming potentials integral (SPI) parameter (Abedian-2013). Since then, the output has changed to a quantitative parameter (QP) (Sim-2014). The purpose of this study was to reanalyzed old...
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Sim-2016C (ICRS2016 Poster).pdf
Sim-2016C (ICRS2016 Abstract Proof).pdf
Sim-2016C (ICRS2016 ePoster).pdf
https://cslide.ctimeetingtech.com/icrs2016/confcal/quenneville

The Verification of the Mechanical Properties of Binder Jetting Manufactured Parts by Instrumented Indentation TestingZhou Y, Tang Y, Hoff T, Garon M and Fiona Yaoyao Zhao43rd Proceedingsof the North American Manufacturing Research. Volume 1, Pages 327–342. (2014)

In order to figure out the mechanical properties of free form biomedical parts made by Additive Manufacturing (AM), Instrumented Indentation Testing (IIT) is introduced to measure the Young’s modulus from the free surface of the parts. The research...
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https://www.researchgate.net/publication/283958401_The_Verification_of_the_Mechanical_Properties_of_Binder_Jetting_Manufactured_Parts_by_Instrumented_Indentation_Testing

Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017

Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin s, to characterize...
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Sim-2017A (ORS2017 Abstract Proof).pdf

Non-destructive electromechanical assessment () of human articular cartilage correlates with histological ss and biomechanical propertiesSim S, Chevrier A, Garon M, Quenneville E, Yaroshinsky A, Hoemann CD and Buschmann MDOsteoarthritis Cartilage, 22(11) 1926-35. (2014)

OBJECTIVE:The hand-held ? device is used to map electromechanical properties...
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https://www.ncbi.nlm.nih.gov/pubmed/25168362

Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilageSim S, Chevrier A, Garon M, Quenneville E, Lavigne P, Yaroshinsky A, Hoemann CD and Buschmann MDJ Orthop Res, 35(4) 858-867. (2017) Epub 2016 Jun 22

Recent advances in the development of new drugs to halt or even reverse the...
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https://www.ncbi.nlm.nih.gov/pubmed/27279435

Freeze-Dried Chitosan-PRP Injectable Surgical Implants for Meniscus Repair: Pilot Feasibility Studies in Ovine ModelsGhazi Zadeh L, Chevrier A, Hurrtig MB, Farr J, Rodeo S, Hoemann CD and Buschmann MDRegen Med Ther, 1(1) 16-29. (2017)

Clinical management of meniscus tears often involves partial meniscectomy, which can lead to Osteoarthritis (OA). Meniscus repair augmentation strategies are being developed to compensate for the tissue’s limited healing response. The purpose...
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https://thescipages.org/Articles/regenerative-medicine/rmt-1-002.pdf

Can the contralateral limb be used as a control during the growing period in a rodent model?Mustafy, T., Londono, I., & Villemure, I.Medical Engineering and Physics, 58, 31–40. https://doi.org/10.1016/j.medengphy.2018.04.013

The contralateral limb is often used as a control in various clinical, forensic and anthropological studies. However, no studies have been performed to determine if the contra-lateral limb is a suitable control during the bone development period. The...
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https://www.medengphys.com/article/S1350-4533(18)30073-0/abstract

A study of saliva lubrication using a compliant oral mimicG. Carpenter, S. Bozorgi, S. Vladescu, A.E. Forte, C. Myant, R.V. Potineni, T. Reddyhoff, and S.K. BaierFood Hydrocolloids, Elsevier, Available online 23 January 2019, https://doi.org/10.1016/j.foodhyd.2019.01.049

Due to ethical issues and the difficulty in obtaining biological tissues, it is important to find synthetic elastomers that can be used as replacement test media for research purposes. An important example of this is friction testing to...
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https://www.sciencedirect.com/science/article/pii/S0268005X1831885X

Experimental and finite element analyses of bone strains in the growing rat tibia induced by in vivo axial compressionTanvir Mustafy, Irène Londono, Isabelle VillemureJournal of the Mechanical Behavior of Biomedical Materials

The objective of this study was to develop and validate a voxel based FE modeling approach to investigate bone strains from in vivo rat tibial compression during the adolescent period. To do so, in vivo strain gauge measurements and voxel based...
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https://doi.org/10.1016/j.jmbbm.2019.03.009

Bioinspired lubrication: from fundamentals to joint protectionX. Banquy, J. Faivre, G. Xie, K. Matyjaszewski, T. Delair, L. David, J. Burdynska, F. Moldovan, S. Benayoun, B. ShresthaICoBT, Montreal, Canada, September 27 2018. Oral presentation S8.1.

Introduction: We describe the design of bioinspired lubricating and wear protecting fluids based on synergistic mixtures of bottle brushes (BB) and linear polymers solutions. To illustrate this concept we used hyaluronic acid (HA) - a naturally...
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Benquy-2018A Normal indentation mapping treated rats.jpg

Long Term Efficacy of Cartilage Repair Induced By scSOX9 in Situ with Bone Marrow-Derived Mesenchymal Stem CellsZhang X, Wu S, Zhu Y, Chu CQArthritis Rheumatol. 2018; 70 (suppl 10). Abstract Number 850

Background/Purpose: Microfracture induces fibrocartilage or fibro-hyaline cartilage both are biomechanically inferior to hyaline cartilage. We reported previously that a super positively charged SOX9 (scSOX9) improved the quality of...
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https://acrabstracts.org/abstract/long-term-efficacy-of-cartilage-repair-induced-by-scsox9-in-situ-with-bone-marrow-derived-mesenchymal-stem-cells/

The effect of two nonresorbable suture types on the mechanical performance over a metal suture anchor eyeletActon D, Perry A, Evans R, Butler A, Stephens P, Bruce W, Goldberg J, Sonnabend D and Walsh WKnee Surgery, Sports Traumatology, Arthroscopy, 2004, 12(2), 165-168

An understanding of the mechanical properties of different suture materials is valuable when selecting the most appropriate suture and repair technique. Sutures should be strong, easy to handle and have high knot security. The introduction of suture...
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https://www.researchgate.net/publication/9886886_The_effect_of_two_nonresorbable_suture_types_on_the_mechanical_performance_over_a_metal_suture_anchor_eyelet

Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodelingArribas SM, Briones AM, Bellingham C, Gonzalez MC, Salaices M, Liu K, Wang Y and Hinek AAm J Physiol Heart Circ Physiol, 2008, 295(6), H2299-2307

Elastin is a major component of conduit arteries and a key determinant of vascular viscoelastic properties. Aberrant organization of elastic lamellae has been reported in resistance vessels from spontaneously hypertensive rats (SHR) before the...
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https://www.ncbi.nlm.nih.gov/pubmed/18849339

Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)

Step-off edges and tissue interfaces are prevalent in cartilage injury such as after intra-articular fracture and reduction, and in focal defects and surgical repair procedures such as osteochondral graft implantation. It would be useful to assess...
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Indentation probing of human articular cartilage: effect on chondrocyte viabilityBae W, Schumacher B and Sah ROsteoarthritis and Cartilage, 15(1), 9-18. (2007)

BACKGROUND: Clinical arthroscopic probes based on indentation testing are being developed. However, the biological effects of certain design parameters (i.e., tip geometry and size) and loading protocols (i.e., indentation depth, rate, and ...
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Novel fluoro-terpolymers for coatings applicationsBaradie B and Shoichet MS.Macromolecules, 38(13), 5560-5568. (2005)

A series of thermally stable, elastomeric and hydrophobic fluoro-terpolymers of tetrafluoroethylene (TFE), vinyl acetate (VAc), and poly(dimethylsiloxane) methyl acrylate-terminated (PDMSMA), P(TFE-ter-VAc-ter-PDMSMA), were synthesized in...
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https://pubs.acs.org/doi/full/10.1021/ma047792s

Biomechanical models for radial distance determination by the rat vibrissal systemBirdwell JA, Solomon JH, Thajchayapong M, Taylor MA, Cheely M, Towal RB, Conradt J and Hartmann MJJournal of neurophysiology, 98(4), 2439-2455. (2007)

Rats use active, rhythmic movements of their whiskers to acquire tactile information about three-dimensional object features. There are no receptors along the length of the whisker; therefore all tactile information must be mechanically transduced...
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https://jn.physiology.org/content/98/4/2439

A comparative biomechanical analysis of term fetal membranes in human and domestic speciesBorazjani A, Weed BC, Patnaik SS, Feugang JM, Christiansen D, Elder SH, Ryan PL and Liao JAmerican journal of obstetrics and gynecology, 204(4), 365. e325-365. e336. (2011)

OBJECTIVE: The purpose of this study was to biomechanically characterize and compare human, porcine, equine, and ovine fetal membranes.

STUDY DESIGN: Noncontact metrology was used for topographic...
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Tensile properties in collagen-rich tissues of Quarter Horses with hereditary equine regional dermal asthenia (HERDA)Bowser J, Elder S, Pasquali M, Grady J, Rashmir-Raven A, Wills R and Swiderski CEquine Vet J. 2014 Mar;46(2):216-22. doi: 10.1111/evj.12110. Epub 2013 Aug 30.

REASONS FOR PERFORMING STUDY: Hereditary equine regional dermal asthenia (HERDA) is an autosomal recessive disorder of Quarter Horses characterised by skin fragility. Horses with HERDA have a missense mutation in peptidyl-prolyl cis-trans...
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https://www.ncbi.nlm.nih.gov/pubmed/23738970

Development and Validation of Large-Sized Engineering Cartilage Constructs in Full-Thickness Chondral Defects in a Rabbit ModelBrenner JMaster thesis Queen's University. (2012)

Long-term applicability of current surgical interventions for the repair of articular cartilage is jeopardized by the formation of mechanically inferior repair tissue. Cartilage tissue engineering offers the possibility of developing functional...
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https://hdl.handle.net/1974/6988

Development of large engineered cartilage constructs from a small population of cellsBrenner JM, Kunz M, Tse MY, Winterborn A, Bardana DD, Pang SC and Waldman SDBiotechnology progress, 29(1), 213-221. (2013)

Confronted with articular cartilage's limited capacity for self-repair, joint resurfacing techniques offer an attractive treatment for damaged or diseased tissue. Although tissue engineered cartilage constructs can be created, a substantial...
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Mechanical response of ankle ligaments at low loadsButler AM and Walsh WRFoot & ankle international, 25(1), 8-12. (2004)

BACKGROUND: The aim of this study was to examine the mechanical behavior of human ankle ligaments at low forces. Predominantly, ankle ligaments have been studied under the auspices of ligament injury. While the mechanical properties of a...
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Assessment of a Regenerative Therapy Strategy for Chondral Defects in Articular CartilageCarroll AThesis Queen’s University, 2015

Osteoarthritis is one of the leading causes of disability in adults over the age of 40 years, and there is currently no curative measure for the disease. As a result, there is a critical need for a strategy that can promote cartilage regeneration. Of...
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https://hdl.handle.net/1974/13628

Association of 3-dimensional cartilage and bone structure with articular cartilage properties in and adjacent to autologous osteochondral grafts after 6 and 12 months in a goat modelChan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG and Sah RLCartilage, 3(3), 255-266. (2012)

The articular cartilage of autologous osteochondral grafts is typically different in structure and function from local host cartilage and thereby presents a remodeling challenge. The hypothesis of this study was that properties of the articular...
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https://car.sagepub.com/content/3/3/255.abstract

A new radiopaque embolizing agent for the treatment of endoleaks after endovascular repair: Influence of contrast agent on chitosan thermogel propertiesCoutu JM, Fatimi A, Berrahmoune S, Soulez G and Lerouge SJournal of Biomedical Materials Research Part B: Applied Biomaterials, 101(1), 153-161. (2013)

A new injectable radiopaque embolizing agent has been developed, based on chitosan thermogelling properties. Different commercial contrast agents (Isovue®, Visipaque®, and Conray®) were associated with chitosan-?-glycerophosphate. Their impact on...
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https://espace.etsmtl.ca/970/

Enhanced mechanical properties in cellulose nanocrystal-poly(oligo ethylene glycol methacrylate) injectable nanocomposite hydrogels through control of physical and chemical cross-linkingDe France KJ, Chan K.J.W, Cranston ED and Hoare TBiomacromolecules. 2016 Feb 8;17(2):649-60. doi: 10.1021/acs.biomac.5b01598. Epub 2016 Jan 15.

While injectable hydrogels have several advantages in the context of biomedical use, their generally weak mechanical properties often limit their applications. Herein, we describe in situ-gelling nanocomposite hydrogels based on poly(oligoethylene...
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https://pubs.acs.org/doi/10.1021/acs.biomac.5b01598
https://www.ncbi.nlm.nih.gov/pubmed/26741744

Determining the modulus of intact bovine vertebral cancellous bone tissue: Development and validation of a protocolEngbretson ACMaster thesis Queen's University. (2010)

Cancellous, or spongy, bone accounts for nearly 80% of the human skeleton’s internal surface area, despite comprising only 20% of its mass. It is made up of a network of struts and plates that provide lightweight internal support to mammalian...
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https://qspace.library.queensu.ca/bitstream/1974/5993/1/Engbretson_Andrew_C_201008_MASc.pdf.pdf

Tuning the Microenvironment: Click-Crosslinked Hyaluronic Acid-Based Hydrogels Provide a Platform for Studying Breast Cancer Cell InvasionFisher SA, Anandakumaran PN, Owen SC and Shoichet MSAdv. Funct. Mater. 2015. DOI: 10.1002/adfm.201502778

A big challenge in cell culture is the non-natural environment in which cells are routinely screened, making in vivo phenomena, such as cell invasion, difficult to understand and predict. To study cancer cell invasion, extracellular matrix (ECM)...
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https://www.ecf.utoronto.ca/~molly/publications/tuning%20the%20microenvironment...breast%20cancer%20cell%20invasion%20(in%20press).pdf

Development of scaffold-free elastic cartilaginous constructs with structural similarities to auricular cartilageGiardini-Rosa R, Joazeiro PP, Thomas K, Collavino K, Weber J and Waldman SDTissue Engineering Part A. Volume 20, Numbers 5 and 6, 2014, pp 1012-26 (2014)

External ear reconstruction with autologous cartilage still remains one of the most difficult problems in the fields of plastic and reconstructive surgery. As the absence of tissue vascularization limits the ability to stimulate new ,...
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https://www.ncbi.nlm.nih.gov/pubmed/24124666

Injectable Interpenetrating Network Hydrogels via Kinetically Orthogonal Reactive Mixing of Functionalized Polymeric PrecursorsGilbert T, Smeets NMB and Hoare TACS Macro Letters, 2015, 4, 1104-1109.

The enhanced mechanics, unique chemistries, and potential for domain formation in interpenetrating network (IPN) hydrogels have attracted significant interest in the context of biomedical applications. However, conventional IPNs are not directly...
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https://pubs.acs.org/doi/abs/10.1021/acsmacrolett.5b00362

Evaluation of a bioabsorable polylactide film in a large animal model for the reduction of retrosternal adhesionsIliopoulos J, Cornwall G, Evans R, Manganas C, Thomas K, Newman D and Walsh WJournal of Surgical Research, 118(2), 144-153. (2004)

OBJECTIVES: An adult pig model of retrosternal adhesion formation via an inferior hemisternotomy was used to evaluate the formation and development of pericardial and retrosternal adhesions, as well as adhesion reduction using two thicknesses...
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https://www.ncbi.nlm.nih.gov/pubmed/15100003

The Aortic Wrap Procedure - A Surgical Method of Treating Age-Related Aortic Dilatation and StiffnessIliopoulos JPhD Thesis, University of New South Wales, Sydney. (2006)

Introduction: There is progressive stiffening and dilatation of the aorta and large elastic arteries with aging as a result of the repetitive cyclic stress they are exposed to throughout life. Aortic stiffening has a number of detrimental...
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https://www.unsworks.unsw.edu.au/primo_library/libweb/action/dlDisplay.do?vid=UNSWORKS&docId=unsworks_1296

Shear mechanics of the TMJ disc - relationship to common clinical observationsJuran CM, Dolwick MF, and McFetridge PSJ Dent Res. 2013 Feb, 92(2):193-8.

The temporomandibular joint (TMJ) is a complex hinge and gliding joint that induces significant shear loads onto the fibrocartilage TMJ disc during jaw motion. The purpose of this study was to assess regional variation in the disc's shear loading...
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https://www.ncbi.nlm.nih.gov/pubmed/?term=Shear+Mechanics+of+the+TMJ+Disc%3A+Relationship+to+Common+Clinical+Observations
https://www.researchgate.net/publication/233724951_Shear_Mechanics_of_the_TMJ_Disc_Relationship_to_Common_Clinical_Observations

Micro-CT visualization and indentation properties of whole meniscus following mercury exposureKolaczek S, Changoor A, Hurtig M, Gordon K and Getgood AAnnual Meeting of the ORS, New Orleans, Louisiana, USA, March 15-18, 2014.

A major risk factor for knee osteoarthritis (OA) is meniscal injury or excision. Surgeons now advocate for meniscal repair or allografts rather than excision with this knowledge in hand. Clinical assessment of the meniscal load sharing is limited...
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https://prgmobileapps.com/AppUpdates/ors/Abstracts/abs1330.html

Engineering of Hyaline Cartilage with a Calcified Zone Using Bone Marrow Stromal CellsLee WD, Hurtig MB, Pilliar RM, Stanford WL and Kandel RAOsteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.010

In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the...
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https://www.ncbi.nlm.nih.gov/pubmed/25891750

Soft Tissue Phantoms for Realistic Needle Insertion - A Comparative StudyLeibinger A, Forte AE, Tan Z, Oldfield MJ, Beyrau F, Dini D and Rodriguez y Baena FAnnals of Biomedical Engineering. pp 1-11 (2015)

Phantoms are common substitutes for soft tissues in biomechanical research and are usually tuned to match tissue properties using standard testing protocols at small strains. However, the response due to complex tool-tissue interactions can differ...
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https://link.springer.com/article/10.1007/s10439-015-1523-0/fulltext.html

Characterization of the effect of microfracture surgery and angle of incidence on the structural properties of femoral boneLiang LD, Wagner A, Steeds J, Hurtig M and Gordon KStudies by Undergraduate Researchers at Guelph, 7(1), 56-61. (2013)

Microfracture surgery is one of the most common treatment options for knee osteoarthritis, a chronic inflammatory disease of the knee joint. However, a recent study by Theodoropoulos et al. (2012) has shown that there are significant variations in...
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https://journal.lib.uoguelph.ca/index.php/surg/article/view/2848

Effects of demineralized bone matrix on tendon-bone healing in an intra-articular rodent modelLovric V, Chen D, Yu Y, Oliver RA, Genin F and Walsh WRThe American journal of sports medicine, 40(10), 2365-2374. (2012)

BACKGROUND: Techniques to improve and accelerate tendon-bone healing could be advantageous in anterior cruciate ligament (ACL) reconstruction. Effects of demineralized bone matrix (DBM) on intra-articular tendon-bone healing have not been...
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https://www.ncbi.nlm.nih.gov/pubmed/22984131

The effect of terminal sterilization on structural and biophysical properties of a decellularized collagen-based scaffold; implications for stem cell adhesionMatuska AM and McFetridge PSJ Biomed Mater Res Part B, 2014, pp 1-10

Terminal sterilization induces physical and chemical changes in the extracellular matrix (ECM) of ex vivo-derived biomaterials due to their aggressive mechanism of action. Prior studies have focused on how sterilization affects the mechanical...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443929/

Biomechanical and biochemical outcomes of porcine temporomandibular joint disc deformationMatuska AM, Muller S, Dolwick MF and McFetridge PSArchives of Oral Biology. 64, 2016, 72–79

Objective: The structure–function relationship in the healthy temporomandibular joint (TMJ) disc has been well established, however the changes in dysfunctional joints has yet to be systematically evaluated. Due to the poor understanding of...
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In vivo dynamic loading reduces bone growth without histomorphometric changes of the growth plateMenard AL, Grimard G, Valteau B, Londono I, Moldovan F and Villemure IJ Orthop Res. 2014 Sep;32(9):1129-36. doi: 10.1002/jor.22664. Epub 2014 Jun 6.

This in vivo study aimed at investigating the effects of dynamic compression on the growth plate. Rats (28 days old) were divided into three dynamically loaded groups, compared with two groups (control, sham). A device was implanted on the 6th and...
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https://www.ncbi.nlm.nih.gov/pubmed/24902946
https://www.researchgate.net/publication/262931706_In_Vivo_Dynamic_Loading_Reduces_Bone_Growth_Without_Histomorphometric_Changes_of_the_Growth_Plate

Static and Dynamic Compression Application and Removal on the Intervertebral Discs of Growing RatsMenard AL, Grimard G, Massol E, Londono I, Moldovan F and Villemure IJournal of Orthopaedic Research Month 2015, pp.1-9. (2015)

Fusionless implants are used to correct pediatric progressive spinal deformities, most of them spanning the intervertebral disc. This study aimed at investigating the effects of in vivo static versus dynamic compression application and removal on...
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https://www.ncbi.nlm.nih.gov/pubmed/24902946

Bone growth resumption following in vivo static and dynamic compression removals on ratsMenard AL, Grimard G, Londono I, Beaudry F, Vachon P, Moldovan F and Villemure IBone. 81 pp. 662-8 doi: 10.1016/j.bone.2015.09.013. (2015)

Mechanical loadings influence bone growth and are used in pediatric treatments of musculoskeletal deformities. This in vivo study aimed at evaluating the effects of static and dynamic compression application and subsequent removal on bone growth,...
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https://www.ncbi.nlm.nih.gov/pubmed/26416149

Hyaluronic acid click hydrogels emulate the extracellular matrixOwen SC, Fisher SA, Tam RY, Nimmo CM and Shoichet MSLangmuir, 29(24), 7393-7400. (2013)

Hydrogels are used to create 3D microenvironments with properties that direct cell function. The current study demonstrates the versatility of hyaluronic acid (HA)-based hydrogels with independent control over hydrogel properties such as mechanics,...
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https://pubs.acs.org/doi/abs/10.1021/la305000w
https://www.ncbi.nlm.nih.gov/pubmed/23343008

The shear mechanical properties of diabetic and non-diabetic plantar soft tissuePai S and Ledoux WRJournal of biomechanics, 45(2), 364-370. (2012)

Changes in the plantar soft tissue shear properties may contribute to ulceration in diabetic patients, however, little is known about these shear parameters. This study examines the elastic and viscoelastic shear behavior of both diabetic and...
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https://www.ncbi.nlm.nih.gov/pubmed/22079385

Longitudinal Stent Deformation: Importance of Stent Type and Stent AppositionPitne, M, van Niekerk E, Dokos S, Pelletier M and Walsh WRAmerican Journal of Biomedical Engineering, 3(3), 63-69. (2013)

Information on stent longitudinal strength is limited to benchtop models using unconstrained stents, consequently having uncertain clinical significance. This study investigated the effects of stent apposition and tube (artery) compliance on stent...
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https://article.sapub.org/10.5923.j.ajbe.20130303.03.html

Low Magnitude High Frequency Vibration Accelerated Cartilage Degeneration but Improved Epiphyseal Bone Formation in Anterior Cruciate Ligament Transect Induced Osteoarthritis Rat ModelQin J, Chow S KH, Guo A, Wong WN., Leung KS and Cheung WHOsteoarthritis and Cartilage. July 2014, Vol.22(7):1061–1067. (2014)

Objectives: To evaluate the effects of low-magnitude high-frequency vibration (LMHFV) on degenerated articular cartilage and subchondral bone in anterior cruciate ligament transection (ACLT) induced osteoarthritis (OA) rat model.

https://www.sciencedirect.com/science/article/pii/S1063458414010838

Growth Factor Stimulation Improves the Structure and Properties of Scaffold-Free Engineered Auricular Cartilage ConstructsRosa RG, Joazeiro PP, Bianco J, Kunz M, Weber JF, et alPLoS ONE 9(8): e105170. doi:10.1371/journal.pone.0105170. (2014)

The reconstruction of the external ear to correct congenital deformities or repair following trauma remains a significant challenge in reconstructive surgery. Previously, we have developed a novel approach to create caffold-free, tissue engineering...
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https://www.ncbi.nlm.nih.gov/pubmed/25126941

Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrateSeguin CA, Grynpas MD, Pilliar RM, Waldman SD and Kandel RASpine, 29(12), 1299-1306. (2004)

STUDY DESIGN: This study describes the formation of nucleus pulposus tissue using a novel tissue engineering approach. OBJECTIVES: To determine if a construct composed of nucleus pulposus tissue on the surface of a calcium polyphosphate...
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https://www.ncbi.nlm.nih.gov/pubmed/15187628
https://www.researchgate.net/publication/8518908_Tissue_Engineered_Nucleus_Pulposus_Tissue_Formed_on_a_Porous_Calcium_Polyphosphate_Substrate

Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null miceSuen RS, Rampersad SN, Stewart DJ and Courtman DWThe American journal of pathology, 179(3), 1549-1559. (2011)

Because both endothelin-1 (ET-1) and angiotensin II (AngII) are independent mediators of arterial remodeling, we sought to determine the role of ET receptor inhibition in AngII-accelerated atherosclerosis and aortic aneurysm formation. We...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157254/

Elastic modulus of 316 stainless steel lattice structure fabricated via binder jetting processTang Y, Zhou Y, Hoff T, Garon M and Zhao FYMaterials Science and Technology 32(7):1743284715Y.000 · June 2015 DOI: 10.1179/1743284715Y.0000000084

This study mainly evaluates the elastic modulus of 316 stainless steel lattice structures fabricated via binder jetting process. In this present research, both solid and lattice samples are designed and fabricated by binder jetting process for two...
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https://www.maneyonline.com/doi/10.1179/1743284715Y.0000000084
https://www.researchgate.net/publication/279157683_Elastic_modulus_of_316_stainless_steel_lattice_structure_fabricated_via_binder_jetting_process

Experimental Evidence of Mechanical Isotropy in Porcine Lung ParenchymaWeed B, Patnaik S, Rougeau-Browning M, Brazile B, Liao J, Prabhu R and Williams LNMaterials 2015, 8 , 2454-2466; doi:10.3390/ma8052454

Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these injuries has...
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https://www.researchgate.net/publication/276518603_Experimental_Evidence_of_Mechanical_Isotropy_in_Porcine_Lung_Parenchyma

Injectable Interpenetrating Network Hydrogels via Kinetically Orthogonal Reactive Mixing of Functionalized Polymeric PrecursorsTrevor G, Niels M. B. Smeets and Hoare TACS Macro Letters, September 16, 2015, 1104–9. doi:10.1021/acsmacrolett.5b00362

https://dx.doi.org/10.1021/acsmacrolett.5b00362

Defective Bone Mineralization and Osteopenia in Young Adult Fgfr3-/- MiceValverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, Ornitz DM and Henderson JEHum Mol Genet, 13(3), 271-284

Mutations that cause constitutive activation of fibroblast growth factor receptor 3 (FGFR3) result in skeletal disorders that are characterized by short-limbed dwarfism and premature closure of cranial sutures. In previous work, it was shown that...
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https://www.ncbi.nlm.nih.gov/pubmed/14681299

Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient miceValverde-Franco G, Binette JS, Li W, Wang H, Chai S, Laflamme F, Tran-Khanh N, Quenneville E, Meijers T, Poole AR, Mort JS, Buschmann MD and Henderson JEHuman molecular genetics, 15(11), 1783-1792. (2006)

Fibroblast growth factor (FGF) receptor 3 has been identified as a key regulator of endochondral bone development and of post-natal bone metabolism through its action on growth plate chondrocytes and osteoblasts, respectively. It has also been shown...
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https://www.ncbi.nlm.nih.gov/pubmed/16624844

Stochastic resonance is a method to improve the biosynthetic response of chondrocytes to mechanical stimulationWeber JF and Waldman SDJournal of Orthopaedic Research 08/2015; DOI:10.1002/jor.23000

Cellular mechanosensitivity is an important factor during the mechanical stimulation of tissue engineered cartilage. While the application of mechanical stimuli improves and properties, chondrocytes also rapidly desensitize under...
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The Effects of Oxidative Stress on the Compressive Damage Thresholds of C2C12 Mouse Myoblasts: Implications for Deep Tissue InjuryYao Y, Xiao Z, Wong S, Hsu YC, Cheng T, Chang CC, Bian L and Mak AFAnn Biomed Eng. 2015 Feb;43(2):287-96. doi: 10.1007/s10439-014-1239-6. Epub 2015 Jan 6.

Deep tissue injury (DTI) is a severe kind of pressure ulcers formed by sustained deformation of muscle tissues over bony prominences. As a major clinical issue, DTI affects people with physical disabilities, and is obviously related to the...
Read More

https://www.ncbi.nlm.nih.gov/pubmed/25558846
https://www.researchgate.net/publication/270596382_The_Effects_of_Oxidative_Stress_on_the_Compressive_Damage_Thresholds_of_C2C12_Mouse_Myoblasts_Implications_for_Deep_Tissue_Injury

Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanocomposite HydrogelsZaragoza J, Babhadiashar N, O’Brien V, Chang A, Blanco M, Zabalegui A, H Lee and Asuri PPLoS ONE 10(8): e0136293. doi:10.1371/journal. pone.0136293. (2015)

Current studies investigating properties of nanoparticle-reinforced polymers have shown that nanocomposites often exhibit improved properties compared to neat polymers. However, over two decades of research, using both experimental studies and...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547727/

Infarcted rat myocardium: Data from biaxial tensile and uniaxial compressive testing and analysis of collagen fibre orientationSirry MS, Butler JR, Patnaik SS, Brazile B, Bertucci R, Claude A, McLaughlin R, Davies NH and Liao JData in Brief 8 (2016) 1338–1343

Myocardial infarction was experimentally induced in rat hearts and harvested immediately, 7, 14 and 28 days after the infarction induction. Anterior wall infarct samples underwent biaxial tensile and uniaxial compressive testing. Orientation of...
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https://www.researchgate.net/publication/305922724_Infarcted_rat_myocardium_Data_from_biaxial_tensile_and_uniaxial_compressive_testing_and_analysis_of_collagen_fibre_orientation

A composite hydrogel for brain tissue phantomsForte AE, Galvan S, Manieri F,y Baena FR and Dini DMaterials & Design, 112, 227-238 (2016)

Synthetic phantoms are valuable tools for training, research and development in traditional and computer aided surgery, but complex organs, such as the brain, are difficult to replicate. Here, we present the development of a new composite hydrogel...
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https://ac.els-cdn.com/S0264127516312370/1-s2.0-S0264127516312370-main.pdf?_tid=0a46be54-8b1f-11e6-a1e0-00000aab0f26&acdnat=1475687791_980f587a916a30065ad493e138d771b0

Biomechanical Characterisation of the Human Auricular Cartilage - Implications for Tissue EngineeringGriffin MF, Premakumar Y, Seifalian M, Szarko and Butler PEMAnnals of Biomedical Engineering, 2016. Punlished online, 14Jul2016. DOI: 10.1007/s10439-016-1688-1

Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to...
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https://www.researchgate.net/publication/305339732_Biomechanical_Characterisation_of_the_Human_Auricular_Cartilages_Implications_for_Tissue_Engineering

Impact of storage conditions on electromechanical, histological and histochemical properties of osteochondral allograftsMickevicius T, Pockevicius A, Kucinskas A, Gudas R, Maciulaitis J, Noreikaite A and Usas ABMC Musculoskeletal Disorders, 16(1), 314. (2015)

Background: Osteochondral allograft transplantation has a good clinical outcome, however, there is still debate on optimization of allograft storage protocol. Storage temperature and nutrient medium composition are the most critical factors...
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Mickevicius-2015A
https://www.researchgate.net/publication/283263142_Impact_of_storage_conditions_on_electromechanical_histological_and_histochemical_properties_of_osteochondral_allografts

Electromechanical Assessment of Human Knee Articular Cartilage with Compression-Induced Streaming PotentialsBecher C, Ricklefs M, Willbold E, Hurschler C, and Abedian RCartilage, 7(1) 62-69. (2016)

To assess the electromechanical properties of human knee articular cartilage with compression-induced streaming potentials for reliability among users and correlation with macroscopic and histological evaluation tools and sulfated glycosaminoglycan...
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Becher-2015.pdf

25th Anniversary Article: Engineering Hydrogels for BiofabricationMalda J, Visser J, Melchels FP, Jüngst T, Hennink WE, Dhert WJA, Groll J and Hutmacher DWAdv. Mater., 25: 5011–5028. doi:10.1002/adma.201302042 (2013)

With advances in tissue engineering, the possibility of regenerating injured tissue or failing organs has become a realistic prospect for the first time in medical history. Tissue engineering - the combination of bioactive materials with cells to...
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https://www.researchgate.net/publication/256612829_25th_Anniversary_Article_Engineering_Hydrogels_for_Biofabrication

Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011

Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease,...
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https://www.researchgate.net/publication/309092382_Tailoring_hydrogel_surface_properties_to_modulate_cellular_response_to_shear_loading

A fibril-network-reinforced biphasic model of cartilage in unconfined compressionSoulhat J, Buschmann MD and Shirazi-Adl AJournal of Biomechanical Engineering, Jun, 121(3), 340-347. (1999)

Cartilage mechanical function relies on a composite structure of a collagen fibrillar network entrapping a proteoglycan matrix. Previous biphasic or poroelastic models of this tissue, which have approximated its composite structure using a...
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https://www.ncbi.nlm.nih.gov/pubmed/10396701

Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21

OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. In the boundary mode of lubrication, load is supported by surface-to-surface contact, a feature that makes this mode...
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https://www.ncbi.nlm.nih.gov/pubmed/16859933

Characterization of tissue engineered cartilage products - Recent developments in advanced therapyMaciulaitis J, Rekstyte S, Usas A, Jankauskaite V, Gudas R, Malinauskas M and Maciulaitis RPharmacological Research 113 (2016) 823–832

Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This relates to cell based medicines, such as tissue engineered cartilage products (TECP) which are increasingly...
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https://www.researchgate.net/publication/310464880_Characterization_of_tissue_engineered_cartilage_products_Recent_developments_in_advanced_therapy_PR_16_JM

Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576

Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed...
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https://www.researchgate.net/publication/50395536

Evaluation of genipin for stabilization of decellularized porcine cartilageElder S, Pinheiro A, Young C, Smith P and Wright EJ Orthop Res. 2016 Nov 18. doi: 10.1002/jor.23483

Abstract

We speculate that an acellular osteochondral xenograft may be a good alternative to allografts for repair of focal articular cartilage lesions. In order to make a xenograft resistant to enzymatic degradation and to...
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https://www.ncbi.nlm.nih.gov/pubmed/?term=Evaluation+of+genipin+for+stabilization+of+decellularized+porcine+cartilage

Strengthening of C2C12 mouse myoblasts against compression damage by mild cyclic compressive stimulationYao Y and Mak AFJ Biomech. 2016 Dec 8;49(16):3956-3961. doi: 10.1016/j.jbiomech.2016.11.050. Epub 2016 Nov 16

Abstract
Deep tissue injury (DTI) is a severe kind of pressure ulcers formed by sustained deformation of muscle tissues over bony prominences. As a major clinical issue, DTI affects people with physical disabilities, and is obviously...
Read More

https://www.ncbi.nlm.nih.gov/pubmed/27884430
https://www.researchgate.net/publication/310657610_Strengthening_of_C2C12_mouse_myoblasts_against_compression_damage_by_mild_cyclic_compressive_stimulation

Improved cartilage integration and interfacial strength after enzymatic treatment in a cartilage transplantation modelvan de Breevaart Bravenboer J, In der Maur CD, Bos PK, Feenstra L, Verhaar JA, Weinans H, van Osch GJArthritis Res Ther. 2004;6(5):R469-76. Epub 2004 Aug 6

The objective of the present study was to investigate whether treatment of articular cartilage with hyaluronidase and collagenase enhances histological and mechanical integration of a cartilage graft into a defect. Discs of 3 mm diameter were taken...
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https://www.researchgate.net/publication/8334961_Improved_cartilage_integration_and_interfacial_strength_after_enzymatic_treatment_in_a_cartilage_transplantation_model
https://www.ncbi.nlm.nih.gov/pubmed/15380046

Comparison of natural crosslinking agents for the stabilization of xenogenic articular cartilagePinheiro A, Cooley A, Liao J, Prabhu R and Elder SJ Orthop Res. 2016 Jun;34(6):1037-46. doi: 10.1002/jor.23121. Epub 2015 Dec 18.

Abstract
Osteochondral xenografts are potentially inexpensive, widely available alternatives to fresh allografts. However, antigen removal from xenogenic cartilage may damage the extracellular matrix and reduce compressive stiffness....
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https://www.ncbi.nlm.nih.gov/pubmed/?term=Comparison+of+natural+crosslinking+agents+for+the+stabilization+of+xenogenic+cartilage

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile TestingGriffin M, Premakumar Y, Seifalian A, Butler PE and Szarko MJournal of Visualized Experiments?: JoVE. 2016;(118):54872. doi:10.3791/54872.

Abstract

Regenerative medicine aims to engineer materials to replace or restore damaged or diseased organs. The mechanical properties of such materials should mimic the human tissues they are aiming to replace; to provide the...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226394/

Study of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.Legrand C, Centonze P, Comblain F, Lambert C, Sanchez C and Henrotin YOsteoarthritis and Cartilage, 25, s314-s315.

Purpose: In animal models, the severity of cartilage damage is assessed Read More

https://orbi.ulg.ac.be/bitstream/2268/209545/1/495.pdf

Addition of excess thyroid hormone induces detrimental changes in human ex vivo full thickness osteochondral explantsHoutman, E.; van Hoolwerff, M.; Ruiz, A. Rodriguez; Lakenberg, N.; Suchiman, E.; Nelissen, R.; Ramos, Y.; Meulenbelt, I.Osteoarthritis and Cartilage 26 (2018) S400 https://doi.org/10.1016/j.joca.2018.02.777

Purpose: By applying 3D in vitro chondrogenesis in a model using human bone marrow mesenchymal stem cells (hBMSC), it was demonstrated that excess thyroid hormone (T3) and the upregulation of deiodinase iodothyronine type-2 (D2) gene (DIO2), had...
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Injectable and degradable Poly(oligoethylene glycol methacrylate)-based hydrogels-synthetic versatility for improved biomaterial designBakaic E, Smeets N, Imbrogno S and Hoare TOral #327.3 on Friday, May 20 from 14:00 to 15:00 in room 524 during World Biomaterials Congress, Montreal, May 2016.

Introduction: Poly(ethylene glycol) (PEG)-based hydrogels are attractive biomaterials due to their hydrophilic, non-cytotoxic and non-immunogenic properties[1]. We recently reported on in situ-gelling PEG-analogue hydrogels based on...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.00728/event_abstract?sname=10th_World_Biomaterials_Congress

Strain Rate Dependence in the Structure Property Relationship of Porcine BrainBegonia MG, Liao J, Horstemeyer MF and Williams LNPaper presented at the ASME 2009 Summer Bioengineering Conference. (2009)

This study examines the internal microstructure evolution of porcine brain during mechanical deformation. Strain rate dependency of porcine brain was investigated under quasi-static compression for strain rates of 0.00625, 0.025, and 0.10 s(-1)....
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Novel Biomechanical Indentation Test Demonstrates Joint Surface Weakening in Mice Lacking Fibroblast Growth Factor Receptor 3 (FGFR3)Binette JS, Laflamme F, Li W, Valverde-Franco G, Tran-Khanh N, Quenneville E, Henderson JE and Buschmann MDPaper presented at the 11th Canadian Connective Tissue Conference, Montreal, QC, Canada. (2005)

Recent advances in murine molecular genetics has enabled the production of mice with targeted disruption of genes that regulate cartilage and bone metabolism. These mice represent excellent models to study the 0 16 Wild Type etiology and progression...
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Binette-CCTC2005-poster.pdf

Mechanically tunable hydrogels for delivery of adipose derived stem cellsCarroll A, Anjum F, Young S, Flynn L and Amsden BGOral# 442.7 on Saturday, May 21 from 16:30 to 18:30 in room 524 during World Biomaterials Congress, Montreal, May 2016

Introduction: Chondroitin sulphate is an important component GAG found in articular cartilage and has a chondroinductive effect on adipose derived stem cells (ASCs). Methacrylate chondroitin sulphate (MCS) has therefore been chosen as a basis...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.02555/event_abstract?sname=10th_World_Biomaterials_Congress

Highly oriented in situ gelling nanocomposite hydrogels as tissue engineering scaffolds for promoting directional cell growthDe France K, Yager KG, Chan KJ, Hoare TR and Cranston EDPoster #P.0554 on Thursday, May 19 from 15:00 to 16:30 in room 220BCD (P3) during World Biomaterials Congress, Montreal, May 2016

Introduction: Patterned hydrogels and polymer scaffolds have attracted attention as platforms for directed cell growth due to the significant impacts cell alignment has on tissue regeneration, mechanical properties and various other cell...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.01953/event_abstract?sname=10th_World_Biomaterials_Congress

Viscoelastic properties of collagen hydrogelsDrouin B, Lévesque L, Lainé A, Rosella E, Loy C and Mantovani DPoster #P.0890 on Thursday, May 19 from 15:00 to 16:30 in room 220BCD (P5) during World Biomaterials Congress, Montreal, May 2016

Introduction: Because of their exceptional biological properties, reconstituted collagen gels are widely used as scaffolds even though their low elastic modulus (~ 500 Pa) limits their applications[1],[2]. The mechanical properties of collagen...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.00535/event_abstract?sname=10th_World_Biomaterials_Congress

Fully injectable hydrazone-thiosuccinimide and hydrazone-disulfide interpenetrating polymer network hydrogels by kinetically orthogonal cross-linking of functionalized PNIPAM and PVP precurGilbert T and Hoare TPoster #P.0058 on Thursday, May 19 from 15:00 to 16:30 in room 220BCD (P1) during World Biomaterials Congress, Montreal, May 2016.

Introduction: IPNs are produced by interlocking two chemically distinct networks in each other’s free volume fraction. This interlocking and the potential for segregation of the IPNs into inhomogeneous domains can cause mechanical properties...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.01047/event_abstract?sname=10th_World_Biomaterials_Congress

Engineering degradable ''smart'' biomedical hydrogels on multiple length scalesHoare TOral #339.2 on Friday, May 20 from 16:30 to 18:30 in room 520B during World Biomaterials Congress, Montreal, May 2016

While multiple types of smart, environmentally-responsive materials have been explored for a variety of biomedical applications (e.g. drug delivery, tissue engineering, bioimaging, etc.), their ultimate clinical use has been hampered by their lack of...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.00250/event_abstract?sname=10th_World_Biomaterials_Congress

Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and SlidingHsu FH, Hui AY, Chen AC, Lotz MK and Sah ROrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256

Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and...
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https://prgmobileapps.com/AppUpdates/ors2015/Abstracts/abs256.html

Poro-viscoelastic models applied to porous gelatin scaffoldsLainé A, Drouin B and Mantovani DPoster #P.0901 on Wed May 18 from 15:00 to 16:30 in room 220BCD (P5) during World Biomaterials Congress, Montreal, May 2016.

Introduction: Scaffolds are among the key components of a tissue-engineered construct. Although many different proteins have been used in scaffold preparation, gelatin, which is obtained by degradation of collagen, is a completely...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.02699/event_abstract?sname=10th_World_Biomaterials_Congress

The effects of frequency on matrix remodeling induced in dynamically strained collagen-based cellularised scaffoldsLevesque L, Loy C, Lainé A, Bono N, Drouin B and Mantovani DOral.238.51 on Wed May 19 from 16:30 to 18:30 in room 519 during World Biomaterials Congress, Montreal, May 2016

Introduction: In vascular tissue engineering, the understanding of cells behavior inside matrices and under pseudo-physiological treatment is of upmost importance in order to develop arteries and arterial wall models. Indeed, extracted...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.00309/event_abstract?sname=10th_World_Biomaterials_Congress

Cellularized collagen gels for tissue engineered vascular wall: in vitro models alternative to in vivo testingLoy C, Meghezi S, Seifu DG, Pezzoli D , Bono N , Levesque L, Drouin B and Mantovani DPoster #P.0616 on Thursday May 19 from 15:00 to 16:30 in room 220BCD (P3) during World Biomaterials Congress, Montreal, May 2016.

Introduction: Type I collagen-gels, as scaffolds for vascular tissue engineering, have a high potential for supporting and guiding vascular cells in the regeneration process. With this in mind, our project was to develop a set of...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.00135/event_abstract?sname=10th_World_Biomaterials_Congress

Changes in Collagen and Sulphated Proteoglycan Synthesis by Multilamellated AF Tissues Cultured in vitro on Aligned Nanofibrous Polyurethane Constructs Under Dynamic Compressive LoadingIu J, Santerre JP and Kandel RAPresentation #331.2 on Fri May 20 from 16:30 to 18:30 in room 511E during the World Congress on Biomechanics, Montreal, May 2016.

Introduction: Current treatments for chronic neck or low back pain are not optimal. The replacement of a degenerated intervertebral disc (IVD) with a bioengineered IVD has been investigated as a potential alternative approach. The IVD is...
Read More

https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.03015/event_abstract?sname=10th_World_Biomaterials_Congress

Dynamic Axial Loading Disrupts Lateral Integration of Arthritic Human Articular Cartilage and Synthetic Tissue Engineered Scaffolds in an Ex Vivo Ring ModelMintz BR, Papaliodis D, Jordan S, Leonard G, Mulligan M and Cooper JAOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Abstract 0390

Introduction: Common surgical procedures including mosaicplasty, microfracture, and autologous chondrocyte implantation to promote articular cartilage regeneration account for ~40% of knee arthroscopy.[1] These procedures are reliant on...
Read More

https://prgmobileapps.com/AppUpdates/ors2015/Abstracts/abs390.html

Contrast-Enhanced Computed Tomography Reflects Stiffness of Intact Articular CartilageNickmanesh R, Stewart R, Snyder B, Grinstaff M and Wilson DISMRM Workshop on Imaging Based Measures of Osteoarthritis. Sept 11-14, 2015. Pacific Grove, CA, USA. Presentation on Sept 13 at 14:39.

Purpose: Articular cartilage distributes load in joints and provides a low-friction surface for joint movement. Glycosaminoglycan (GAG) in cartilage plays a critical role in its compressive stiffness. Loss of GAG is an early sign of...
Read More

Nickmanesh-IWOAI2015-abstract.pdf

The Effect Of Superimposed Vibrations On Chondrocytes Subjected To Dynamic Compressive LoadingWeber J and Waldman SOrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 1244

Introduction: Mechanical stimulation is often used as a means to accelerate and improve the growth and properties of tissue engineered cartilage constructs. However, as cartilage cells (chondrocytes) rapidly desensitize to the imposed stimulus...
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https://prgmobileapps.com/AppUpdates/ors2015/Abstracts/abs1244.html

Direct reactive electrospinning of degradable hydrogel nanofibers for tissue engineeringXu F, Gough I and Hoare TOral #520.5 on Sunday, May 22 from 14:00 to 16:00 in room 516C during World Biomaterials Congress, Montreal, May 2016.

Hydrogels have received considerable attention in the context of soft tissue engineering due to their as high water contents, (general) cell compatibility, and physicochemical and mechanical similarities to native soft tissues[1]. Most hydrogels used...
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https://www.frontiersin.org/10.3389/conf.FBIOE.2016.01.01238/event_abstract?sname=10th_World_Biomaterials_Congress

Electroarthrography, a non-invasive streaming potential-based method, measures cartilage quality in live horsesChangoor A, Brett W, Hoba MA, Garon M, Quenneville E, Gordon K, Savard P, Buschmann MD, Hurtig MB and Trout DROsteoarthritis and Cartilage, Vol. 22, Supplement 1, 138, World Congress on Osteoarthritis, April 2014, Paris, France.

Introduction: Degenerative joint diseases, including osteoarthritis, are characterized by progressive cartilage degeneration, which can lead to pain and loss of joint function. Therapeutics administered early, when only low grade cartilage...
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Changoor-OARSI2014-Poster.pdf

Non-invasive Electroarthrography Correlates to Direct Measurements of Cartilage Streaming Potentials in Weight Bearing Regions of Equine Metacarpophalangeal (Fetlock) JointsChangoor A, Hoba MA, Garon M, Quenneville E, Gordon K, Savard P, Buschmann MD and Hurtig MBTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, 1123 (2014)

Introduction/Purpose: Electroarthrography (EAG) is a new technology that non-invasively measures cartilage streaming potentials through electrodes contacting the skin surrounding an articular joint. Streaming potentials are produced during...
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Changoor-ORS2014.pdf

Freeze-dried chitosan-PRP implants improve meniscus repair in an ovine modelGhazi Zadeh L, Chevrier A, Hurtig M, Farr J, Rodeo S, Hoemann C and Buschmann MInternational Cartilage Repair Society (ICRS), Sorrento, 2016, Poster P112

Purpose: Menisci are structurally complex and play an essential weight-??bearing role in the knee joint. Although there has been a recent increase in the number of meniscus repairs performed yearly in the US [1], only a small number of all...
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Zadeh-2016A ICRS2016 Poster
https://cslide.ctimeetingtech.com/icrs2016/confcal/ghazi

Streaming Potential-Based Arthroscopic Device Discerns Topographical Differences In Cartilage Covered And Uncovered By Meniscus In Ovine Stifle JointsChangoor A, Quenneville E, Garon M, Cloutier L, Hurtig MB and Buschmann MDTransactions of the 53th Annual Meeting of the Orthopaedic Research Society, San Diego, CA, USA, 32:631. (2007)

Animal models of osteoarthritis have been used for understanding diseaseprogression and are essential for assessing potential new therapies. Ovine models, such as the lateral meniscectomy model, are of interest because meniscectomy models often...
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Changoor-ORS2007-poster.pdf

Electroarthrography Provides a Non-invasive Streaming Potential-Based Method for Detecting Cartilage Degeneration in an Equine Model TransactionsChangoor A, Hoba MA, Quenneville E, Garon M, Gordon K, Buschmann MD, Savard P and Hurtig MBThe 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, USA, 1974. (2013)

Degenerative joint diseases, like osteoarthritis, are characterized by progressive cartilage degeneration, which can lead to pain and loss of mobility. Low-grade cartilage deterioration occurs early in disease progression and may be treatable....
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Changoor-2013-Poster.pdf

Assessment of allograft performance in vivo using electromechanical properties of articular cartilageUsas A, Mickevicius T, Pockevicius A, Kucinskas A, Maciulaitis J and Gudas RInternational Cartilage Repair Society (ICRS), Sorrento, 2016, Poster P211

Purpose: Clinical outcome of osteochondral allograft transplantation (OAT) depends on allograft quality. There is a lack of rapid and reliable non-destructive methods for intraoperative evaluation of repaired cartilage. Measurement of...
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https://cslide.ctimeetingtech.com/icrs2016/confcal/usas

Biomechanical characterisation of the human nasal cartilages - implications for tissue engineeringGriffin MF, Premakumar Y, Seifalian AM, Szarko M and Butler PEMJournal of Materials Science: Materials in Medicine, 27(1), 1-6. (2016)

Nasal reconstruction is currently performed using autologous grafts provides but is limited by donor site morbidity, tissue availability and potentially graft failure. Additionally, current alternative alloplastic materials are limited by their high...
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Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)

There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte...
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https://www.ncbi.nlm.nih.gov/pubmed/25920896

Decrease of the electrical potentials measured on the surface of the knee and produced by cartilage compression during successive loading cyclesZhu L, Garon M, Quenneville E, Buschmann MD and Savard PJournal of Biomechanics, 49(14), 3587-3591. (2016)

Electroarthrography (EAG) is a new technique formeasuring electrical potentials appearing on the knee surface during loadingthat reflects cartilage quality and joint contact force. Our objective was toinvestigate the evolution of EAG signals during...
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https://www.ncbi.nlm.nih.gov/pubmed/27653377
https://www.researchgate.net/publication/308352591_Decrease_of_the_electrical_potentials_measured_on_the_surface_of_the_knee_and_produced_by_cartilage_compression_during_successive_loading_cycles

Mechanical loading of knee articular cartilage induced by muscle contraction can be assessed by measuring electrical potentials at the surface of the kneeZhu L, Buschmann MD and Savard PJournal of biomechanics, 49(3), 338-343. (2016)

Electroarthrography (EAG) consists of recording electrical potentials on the knee surface that originate from streaming potentials within articular cartilage while the joint is undergoing compressive loading. The aim was to investigate how the...
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https://www.researchgate.net/publication/288919310_Mechanical_loading_of_knee_articular_cartilage_induced_by_muscle_contraction_can_be_assessed_by_measuring_electrical_potentials_at_the_surface_of_the_knee

Change in viability of C2C12 myoblasts under compression, shear and oxidative challengesHong Y, Yao Y, Wong S, Bian L and Mak AFJournal of biomechanics, 49(8), 1305-1310. (2016)

Skeletal and epidermal loadings can damage muscle cells and contribute to the development of deep tissue injury (DTI) – a severe kind of pressure ulcers affecting many people with disability. Important predisposing factors include the multiaxial...
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https://www.ncbi.nlm.nih.gov/pubmed/27017299
https://www.researchgate.net/publication/270596382_The_Effects_of_Oxidative_Stress_on_the_Compressive_Damage_Thresholds_of_C2C12_Mouse_Myoblasts_Implications_for_Deep_Tissue_Injury
https://www.researchgate.net/publication/270596382_The_Effects_of_Oxidative_Stress_on_the_Compressive_Damage_Thresholds_of_C2C12_Mouse_Myoblasts_Implications_for_Deep_Tissue_Injury/figures

Biomechanics and MechanoBiology of Human Cartilage ArticulationHsu FH, Alonso E, Raleigh AR, Saleh AA, Masuda K, Lotz MK, Chen AC and Sah ROrthopeadic Research Society Annual Meeting, 2016, Orlando, USA, Poster abstract 1428

Introduction: During joint articulation, cartilage, particularly that near the articular surface, undergoes a complex combination of compression, shear, and sliding.1,2 In vitro analyses have focused on cartilage biomechanics in response...
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https://www.ors.org/Transactions/62/1428.pdf

Effects of Biowastes Released by Mechanically Damaged Muscle Cells on the Propagation of Deep Tissue Injury: A Multiphysics StudyYao Y, Da Ong LX, Li X, Wan K and Mak AFAnnals of Biomedical Engineering March 2017, Volume 45, Issue 3, pp 761–774

Deep tissue injuries occur in muscle tissues around bony prominences under mechanical loading leading to severe pressure ulcers. Tissue compression can potentially compromise...
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Changes in growth plate extracellular matrix composition and biomechanics following in vitro static versus dynamic mechanical modulationKaviani R, Londono I, Parent S, Moldovan F and Villemure IJ Musculoskelet Neuronal Interact, 1-11 (2017)

The objective of this study was to investigate the effects of mechanical modulation parameters on structural proteins biocomposition and mechanical properties of the growth plate. Establishing these parameters is a crucial step in the...
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https://www.ismni.org/jmni/accepted/jmni_aa_KAVIANI.pdf

Injectable Poly(oligoethylene glycol methacrylate)-Based Hydrogels Fabricated from Highly Branched Precursor Polymers: Controlling Gel Properties by Precursor Polymer MorphologyIvan Urosev, Helen Dorrington, Nicola Muzzin, Richard Alsop, Emilia Bakaic, Trevor Gilbert, Maikel Rheinst?dter and Todd HoareACS Applied Polymer Materials, 2019, 1, 3, 369-380 January 24, 2019 https://doi.org/10.1021/acsapm.8b00085

The physicochemical properties of injectable hydrogels are typically modified by altering the chemistry of the precursor polymer and/or the amount or type of cross-linker, both of which can lead to hydrogels with altered mechanics, swelling,...
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https://pubs.acs.org/doi/10.1021/acsapm.8b00085

Intervertebral disc implantR Kandel, JP Santerre, SQ LiUS Patent App. 10195044, 2019

The present inventors have generated the tissues that comprise the intervertebral disc and have established viable protocols and tissue conditions that facilitate integration of all the tissue components into one functional tissue so it can...
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https://patentimages.storage.googleapis.com/42/7a/ef/ff71221c3da781/US10195044.pdf

Comparative study on complexes formed by chitosan and different polyanions: Potential of chitosan-pectin biomaterials as scaffolds in tissue engineeringFernanda Carla Bombaldi de Souza, Renata Francielle Bombaldi de Souza, Bernard Drouin, Diego Mantovani and Angela Maria MoraesInternational Journal of Biological Macromolecules, Volume 132, 1 July 2019, Pages 178-189

Polyelectrolyte complexes of chitosan (Ch) and pectin (Pc) or alginate (Alg) were produced in the presence or absence of the silicone gel Silpuran® 2130 A/B (Sil) and the surfactant Kolliphor® P188 (Kol). Ch-Pc-Kol-based formulations presented...
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https://www.sciencedirect.com/science/article/pii/S0141813019308141

Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive ManufacturingDeng X, Attalla R, Sadowski LP, Chen M, Majcher MJ, Urosev I, Yin D-C, Selvaganapathy PR, Filipe CDM and Hoare TBiomacromolecules 2017, Published Online, doi: 10.1021/acs.biomac.7b01243

We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic crosslinking between 2-aminophenylboronic acid-functionalized...
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https://www.ncbi.nlm.nih.gov/pubmed/29168379

Mechanically resilient injectable scaffolds for intramuscular stem cell delivery and cytokine releaseYoung SA, Sherman SE, Cooper TT, Brown C, Anjum F, Hess DA. Flynn LE and Amsden BGBiomaterials. doi: https://doi.org/10.1016/j.biomaterials.2018.01.008 (2018)

A promising strategy for treating peripheral ischemia involves the delivery of stem cells to promote angiogenesis through paracrine signaling. Treatment success depends on cell localization, retention, and survival within the mechanically dynamic...
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https://www.sciencedirect.com/science/article/pii/S0142961218300085

Ermittlung mechanischer Kennwerte mittels IndentationSeidenstucker MBioNanoMat. 2015; 16 (2-3): 152–156 DOI 10.1515/bnm-2015-9014

(In Germany only) In der Materialprüfung sind Indentationsverfahren bereits seit Jahren g?ngige Praxis. Jedoch war es bisher nicht so ohne weiteres m?glich Gewebeproben, insbesondere Weichgewebe wie Knorpel zu untersuchen. Mit dem Mikroindenter...
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Seidenstucker-2015-presentation.pdf
Seidenstucker-2015.pdf

Guidelines for an optimized indentation protocol for measurement of cartilage stiffness - The effects of spatial variation and indentation parametersMoshtagh PR, Pouran B, Korthagen NM, Zadpoor AA and Weinans HJournal of Biomechanics 49(14) · September 2016 DOI: 10.1016/j.jbiomech.2016.09.020

Mechanical properties of articular cartilage that are vital to its function are often determined by indentation tests, which can be performed at different scales. Cartilage tissue exhibits various types of structural, geometrical, and spatial...
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https://www.ncbi.nlm.nih.gov/pubmed/27660171
https://www.researchgate.net/publication/308351970_Guidelines_for_an_optimized_indentation_protocol_for_measurement_of_cartilage_stiffness_The_effects_of_spatial_variation_and_indentation_parameters

Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear.Chen J, Brazile B, Prabhu R, Patnaik SS, Bertucci R, Rhee H, Horstemeyer MF, Hong Y, Williams LN, Liao JJ Biomech Eng. 2018 Jul 1;140(7). doi: 10.1115/1.4039825.

In this study, the damage evolution of liver tissue was quantified at the microstructural level under tensile, compression, and...
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https://www.ncbi.nlm.nih.gov/pubmed/29715364

Contrast-Enhanced Computed Tomography (CECT) attenuation is associated with stiffness of intact knee cartilageNickmanesh, Reza; Stewart, Rachel C.; Snyder, Brian D.; Grinstaff, Mark W.; Masri, Bassam A.; Wilson, David R.J. Orthop. Res. First published: 17 April 2018 doi:10.1002/jor.24022

Contrast?enhanced computed tomography (CECT) using charged contrast?agents enables quantification of cartilage glycosaminoglycan content. Since glycosaminoglycan content is a key determinant of cartilage compressive stiffness, CECT measurements have...
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https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.24022

Development of a Breast Cancer Cell Microenvironment in Three-Dimensional Hyaluronic Acid Based HydrogelsFisher, Stephanie Anne.Thesis, University of Toronto. (2018)

Breast cancer cell invasion is influenced by the tumor microenvironment including the extracellular matrix, mechanical properties, stromal cells, and bioactive factors. To elucidate the role of the microenvironment on cell invasion, defined...
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https://tspace.library.utoronto.ca/handle/1807/89784

Effects of bone damage on creep behaviours of human vertebral trabeculaeO'Callaghan, Paul; Szarko, Matthew; Wang, Yue; Luo, JinBone Volume 106, January 2018, Pages 204-210 https://doi.org/10.1016/j.bone.2017.10.022

A subgroup of patients suffering with vertebral fractures can develop progressive spinal deformities over time. The mechanism underlying such clinical observation, however, remains unknown. Previous studies suggested that creep deformation of the...
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https://www.sciencedirect.com/science/article/pii/S8756328217303885

Fibronectin promotes elastin deposition, elasticity and mechanical strength in cellularised collagen-based scaffoldsPezzoli, Daniele; Di Paolo, Joseph; Kumra, Heena; Fois, Giulia; Candiani, Gabriele; Reinhardt, Dieter P.; Mantovani, DiegoBiomaterials Volume 180, October 2018, Pages 130-142 https://doi.org/10.1016/j.biomaterials.2018.07.013

One of the tightest bottlenecks in vascular tissue engineering (vTE) is the lack of strength and elasticity of engineered vascular wall models caused by limited elastic fiber deposition. In this study, flat and tubular collagen gel-based scaffolds...
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https://www.sciencedirect.com/science/article/pii/S0142961218304903

Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivoLegrand, Catherine; Ahmed, Usman; Anwar, Attia; Rajpoot, Kashif; Pasha, Sabah; Lambert, Cecile; Davidson, Rose K.; Clark, Ian M.; Thornalley, Paul J.; Henrotin, YvesArthritis Research & Therapy 2018 20:131 https://doi.org/10.1186/s13075-018-1636-6

Background

Changes of serum concentrations of glycated, oxidized, and nitrated amino acids and hydroxyproline and anticyclic citrullinated peptide antibody status combined by machine learning techniques in algorithms have recently been found to...
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https://www.ncbi.nlm.nih.gov/pubmed/29929535

In Situ Cross-Linking of Poly (vinyl alcohol)/Graphene Oxide–Polyethylene Glycol Nanocomposite Hydrogels as Artificial Cartilage Replacement: Intercalation Structure, Unconfined Compressive Behavior, and Biotribological BehaviorsMeng, Yeqiao; Ye, Lin; Coates, Phil; Twigg, PeterJ. Phys. Chem. C, 2018, 122 (5), pp 3157–3167 DOI: 10.1021/acs.jpcc.7b12465

Poly(vinyl alcohol) (PVA)/graphene oxide (GO) nanocomposite hydrogel as artificial cartilage replacement was prepared via freezing/thawing method by introducing polyethylene glycol (PEG). Efficient grafting of PVA molecules onto GO surface was...
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https://pubs.acs.org/doi/abs/10.1021/acs.jpcc.7b12465

Investigating the role of in vivo cell cycle activation within mesenchymal stem cells in the regenerative potential of articular cartilage after injuryMasson, A. O.; Underhill, T. M.; Edwards, W. B.; Krawetz, R. J.Osteoarthritis and Cartilage 26 (2018) S38 https://doi.org/10.1016/j.joca.2018.02.092

Purpose: Cartilage has intrinsic poor healing capacity after injury, which can lead to the development of degenerative diseases such as osteoarthritis (OA). Current treatments for OA are unable to effectively stop or delay disease progression. Hence,...
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https://www.sciencedirect.com/science/article/pii/S1063458418301924
https://www.oarsijournal.com/article/S1063-4584(18)30192-4/abstract

Mechanically enhanced nested-network hydrogels as a coating material for biomedical devicesWang, Zhengmu; Zhang, Hongbin; Chu, Axel J.; Jackson, John; Lin, Karen; Lim, Chinten James; Lange, Dirk; Chiao, MuActa Biomaterialia Volume 70, 1 April 2018, Pages 98-109 https://doi.org/10.1016/j.actbio.2018.02.003

Well-organized composite formations such as hierarchical nested-network (NN) structure in bone tissue and reticular connective tissue present remarkable mechanical strength and play a crucial role in achieving physical and biological functions for...
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https://www.sciencedirect.com/science/article/pii/S1742706118300734

Models and tissue mimics for brain shift simulationsForte, Antonio E.; Galvan, Stefano; Dini, DanieleBiomech Model Mechanobiol (2018) 17: 249. https://doi.org/10.1007/s10237-017-0958-7

Capturing the deformation of human brain during neurosurgical operations is an extremely important task to improve the accuracy or surgical procedure and minimize permanent damage in patients. This study focuses on the development of an accurate...
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https://link.springer.com/article/10.1007/s10237-017-0958-7

Morphology of cross-linked cellulose nanocrystal aerogels: cryo-templating versus pressurized gas expansion processingOsorio, Daniel A.; Seifried, Bernhard; Moquin, Paul; Grandfield, Kathryn; Cranston, Emily D.Journal of Materials Science July 2018, Volume 53, Issue 13, pp 9842–9860

Cellulose nanocrystal (CNC)-based aerogels are often produced through cryo-templating, followed by either critical point drying or freeze drying. While cryo-templating gives aerogels with a bimodal pore size distribution, better morphological control...
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https://link.springer.com/article/10.1007/s10853-018-2235-2

Nanocolloidal Hydrogel for Heavy Metal ScavengingAlizadehgiashi, Moien; Khuu, Nancy; Khabibullin, Amir; Henry, Andria; Tebbe, Moritz; Suzuki, Toyoko; Kumacheva, EugeniaACS Nano, Article ASAP DOI: 10.1021/acsnano.8b03202 Publication Date (Web): July 6, 2018

We report a nanocolloidal hydrogel that combines the advantages of molecular hydrogels and nanoparticle-based scavengers of heavy metal ions. The hydrogel was formed by the chemical cross-linking of cellulose nanocrystals and graphene quantum dots....
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https://pubs.acs.org/doi/abs/10.1021/acsnano.8b03202

Optimising the decellularization of human elastic cartilage with trypsin for future use in ear reconstructionRahman, Shafiq; Griffin, Michelle; Naik, Anish; Szarko, Matthew; Butler, Peter EMScientific Reports (2018) 8:3097 DOI:10.1038/s41598-018-20592-x

Decellularized scaffolds can induce chondrogenic differentiation of stem cells. This study compares different methods to optimise the decellularization of auricular cartilage. The process consisted of an initial 12?hour dry freeze thaw which froze...
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https://www.nature.com/articles/s41598-018-20592-x

Patterning of Structurally Anisotropic Composite Hydrogel SheetsPrince, Elisabeth; Alizadehgiashi, Moien; Campbell, Melissa; Khuu, Nancy; Albulescu, Alexandra; De France, Kevin; Ratkov, Dimitrije; Li, Yunfeng; Hoare, Todd; Kumacheva, EugeniaBiomacromolecules, 2018, 19 (4), pp 1276–1284 DOI: 10.1021/acs.biomac.8b00100

Compositional and structural patterns play a crucial role in the function of many biological tissues. In the present work, for nanofibrillar hydrogels formed by chemically cross-linked cellulose nanocrystals (CNC) and gelatin, we report a...
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https://pubs.acs.org/doi/abs/10.1021/acs.biomac.8b00100

Quantifying the Effects of Different Treadmill Training Speeds and Durations on the Health of Rat Knee JointsRios, Jaqueline Lourdes; Boldt, Kevin Rudi; Mather, James William; Seerattan, Ruth Anne; Hart, David Arthur; Herzog, WalterSports Medicine - Open 2018 4:15 https://doi.org/10.1186/s40798-018-0127-2

Background Walking and running provide cyclical loading to the knee which is thought essential for joint health within a physiological window. However, exercising outside the physiological window, e.g. excessive cyclical loading, may produce loading...
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https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-018-0127-2

Tribological evaluation of biomedical polycarbonate urethanes against articular cartilageKanca, Yusuf; Milner, Piers; Dini, Daniele; Amis, Andrew A.Journal of the Mechanical Behavior of Biomedical Materials Volume 82, June 2018, Pages 394-402 https://doi.org/10.1016/j.jmbbm.2018.04.001

This research investigated the in-vitro wear and friction performance of polycarbonate urethane (PCU) 80A as they interact with articular cartilage, using a customised multidirectional pin-on-plate tester. Condyles were articulated against PCU 80A...
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https://www.sciencedirect.com/science/article/pii/S1751616118304326

Tribological properties of PVA/PVP blend hydrogels against articular cartilageKanca, Yusuf; Milner, Piers; Dini, Daniele; Amis, Andrew A.Journal of the Mechanical Behavior of Biomedical Materials Volume 78, February 2018, Pages 36-45 https://doi.org/10.1016/j.jmbbm.2017.10.027

This research investigated in-vitro tribological performance of the articulation of cartilage-on- polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) blend hydrogels using a custom-designed multi-directional wear rig. The hydrogels were prepared...
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https://www.sciencedirect.com/science/article/pii/S1751616117304629

Visible Light Photoinitiation of Cell Adhesive Gelatin Methacryloyl Hydrogels for Stereolithography 3D BioprintingWang, Zongjie; Kumar, Hitendra; Tian, Zhenlin; Jin, Xian; Holzman, Jonathan F.; Menard, Frederic; Kim, KeekyoungACS Appl. Mater. Interfaces, Just Accepted Manuscript DOI: 10.1021/acsami.8b06607 Publication Date (Web): July 19, 2018

We present the first cell attachable and visible light crosslinkable hydrogels based on gelatin methacryloyl (GelMA) with eosin Y (EY) photoinitiation for stereolithography 3D bioprinting. In order to develop visible a light crosslinkable hydrogel,...
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https://pubs.acs.org/doi/abs/10.1021/acsami.8b06607

Peptide-modified methacrylated glycol chitosan hydrogels as a cell-viability supporting pro-angiogenic cell delivery platform for human adipose-derived stem/stromal cellsDhillon J, Young SA, Sherman SE, Bell GI, Amsden BG, Hess DA, Flynn LEJ Biomed Mater Res A. 2018 Nov 3. doi: 10.1002/jbm.a.36573.

Cell-based therapies involving the injection of adipose-derived stem/stromal cells (ASCs) within rationally designed biomaterials...
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https://www.ncbi.nlm.nih.gov/pubmed/30390406?report=abstract

Magnesium phosphate hydrogelsF Tamimi Marino, A Ali Al-Hashedi, M Laurenti, A Ebraheem Al Subaie, M-N Abdallah, I Tamimi Marinohttps://patents.google.com/patent/US20190002282A1/en

The present invention relates to magnesium phosphate hydrogels. More specifically, the present invention is concerned with such gels and their uses as scaffolds for bone tissue engineering, as drug delivery systems and in pastes for cleaning dental...
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https://patents.google.com/patent/US20190002282A1/en

Injectable Poly(Oligoethylene Glycol Methacrylate)-Based Hydrogels Fabricated from Highly Branched Precursor Polymers: Controlling Gel Properties by Precursor Polymer MorphologyI. Urosev, H. Dorrington, N. Muzzin, R.J. Alsop, E. Bakaic, T. Gilbert, M.C. Rheinstadter, and T. HoareACS Applied Polymer Materials Just Accepted Manuscript, DOI: 10.1021/acsapm.8b00085

The physicochemical properties of injectable hydrogels are typically modified by altering the chemistry of the precursor polymer and/or the...
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https://pubs.acs.org/doi/pdf/10.1021/acsapm.8b00085

Tough, Semisynthetic Hydrogels for Adipose Derived Stem Cell Delivery for Chondral Defect RepairAnjum F, Carroll A, Young SA, Flynn LE and Amsden BGMacromol Biosci. 2017 Jan 13. doi: 10.1002/mabi.201600373.

Cell-based therapies have great potential to regenerate and repair injured articular cartilage, and a range of synthetic and natural polymer-based hydrogels have been used in combination with stem cells and growth factors for this purpose. Although...
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https://www.ncbi.nlm.nih.gov/pubmed/28085994

Cryogenic 3D Printing of Super Soft HydrogelsForte AE, Parisi C, Dini D, Di Silvio L and Tan ZScientific Reports 7, Article number: 16293 (2017) doi:10.1038/s41598-017-16668-9

Conventional 3D bioprinting allows fabrication of 3D scaffolds for biomedical applications. In this contribution we present a cryogenic 3D printing method able to produce stable 3D structures by utilising the liquid to solid phase change of a...
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https://www.nature.com/articles/s41598-017-16668-9?WT.feed_name=subjects_scientific-community-and-society

Characterization of a novel decellularized bone marrow scaffold as an inductive environment for hematopoietic stem cellsJ.E. Romero Bianco, R. Giardini Rosa, A. Congrains-Castillo, P.P. Joazeiro, S.D. Waldman, J.F. Weber, and S.T. Olalla SaadBiomater. Sci., 2019, Advance Article, first published on 19 Jan 2019, DOI 10.1039/C8BM01503A

Due to the increasing demand for a bone marrow study model, we developed a natural...
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https://pubs.rsc.org/en/content/articlelanding/2019/bm/c8bm01503a#!divAbstract

Comparative study of gelatin methacrylate hydrogels from different sources for biofabrication applicationsZongjie Wang, Zhenlin Tian, Fredric Menard and Keekyoung KimBiofabrication, Volume 9, Number 4, Published 21 August 2017 © 2017 IOP Publishing

Gelatin methacrylate (GelMA) hydrogel is a promising bioink for biofabrication applications due to its cost-effectiveness, ease of synthesis and biocompatibility to allow cell adhesion. However, the GelMA synthesized from a widely used porcine skin...
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https://iopscience.iop.org/article/10.1088/1758-5090/aa83cf

Effect of Multiple Confined Compression/Stress Relaxation Cycles on Cross-linked Alginate Pore SizeKolar Venkat S, Risa EL, Antell B and Mobed-Miremadi MBiomedical Engineering Society 2017 (BMES) Phoenix - Arizona

Introduction: Alginate is a biopolymer and hydrogel comprised of (1,4)-linked ?-D-mannuronic (M) and (1,3)-?- L-guluronic (G) acid residues. The average pore size associated with crosslinked high MW 1-2 (w/v%) alginate structures has been...
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https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=1061&context=bmes

Dynamic covalent Schiff-base silicone polymers and elastomersRobert Bui and Michael A. BrookPolymer. Volume 160, 3 January 2019, Pages 282-290 https://doi.org/10.1016/j.polymer.2018.11.043

Polymers with dynamically exchanging crosslinks possess the ability to be repurposed, in whole or part, following a stimulus. The ability of imines to undergo dynamic exchange reactions under mild conditions was utilized to chain extend or crosslink...
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https://www.sciencedirect.com/science/article/pii/S0032386118310711

Growth and Characterization of Multicellular Spheroids in Cellulose Derived Hydrogels as an Artificial Three-Dimensional ScaffoldMelissa CampbellUniversity of Toronto

The Young’s modulus of each hydrogel was performed on a MachOne Mechanical tester (BMM Inc., QC) using cyclic compression and parallel plate geometry. The hydrogels for testing were pre-formed into disks measuring 3.25 mm in height by...
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Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage LesionsSchmal, Hagen; Kowal, Justyna M.; Kassem, Moustapha; Seidenstuecker, Michael; Bernstein, Anke; B?ttiger, Katharina; Xiong, Tanshiyue; Sudkamp, Norbert P.; Kubosch, Eva J.Stem Cells International Volume 2018, Article ID 4142031, 12 pages https://doi.org/10.1155/2018/4142031

Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated...
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https://www.hindawi.com/journals/sci/2018/4142031/

Laser micro-ablation of fibrocartilage tissue: Effects of tissue processing on porosity modification and mechanicsMatuska, A. M.; McFetridge, P. S.J Biomed Mater Res Part B 2018:106B:1858–1868. https://doi.org/10.1002/jbm.b.33997

The temporomandibular joint disk (TMJd) is an extremely dense and avascular fibrocartilaginous extracellular matrix (ECM) resulting in a limited regenerative capacity. The use of decellularized TMJd as a biocompatible scaffold to guide tissue...
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Comparison of crystallization characteristics and mechanical properties of polypropylene processed by ultrasound and conventional micro-injection moldingMasato, D., Babenko, M., Shriky, B., Gough, T., Lucchetta, G., & Whiteside, B.Int J Adv Manuf Technol (2018). https://doi.org/10.1007/s00170-018-2493-9

Ultrasound injection molding has emerged as an alternative production route for the manufacturing of micro-scale polymeric components, where it offers significant benefits over the conventional micro-injection molding process. In this work, the...
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https://link.springer.com/article/10.1007/s00170-018-2493-9

Supramolecular hydrogels cross-linked by preassembled host–guest PEG cross-linkers resist excessive, ultrafast, and non-resting cyclic compressionChen, X., Dong, C., Wei, K., Yao, Y., Feng, Q., Zhang, K., … Bian, L.Chen, X. et al. NPG Asia Materials 1 (2018). doi:10.1038/s41427-018-0071-0

This study is to investigate and systemically study the mechanical performance of supramolecular PEG hydrogels in comparison with those of the chemical hydrogels cross-linked by conventional PEG diacrylate (PEGDA). The supramolecular cross-links...
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https://www.nature.com/articles/s41427-018-0071-0

Stochastic Resonance with Dynamic Compression Improves the Growth of Adult Chondrocytes in Agarose Gel ConstructsWeber, J. F., Chiu, L. L. Y., Balko, S., & Waldman, S. D.Weber, J.F., Chiu, L.L., Balko, S. et al. Ann Biomed Eng (2018). https://doi.org/10.1007/s10439-018-02123-x

Dynamic mechanical stimulation has been an effective method to improve the growth of tissue engineering cartilage constructs derived from immature cells. However, when more mature cell populations are used, results are often variable due to the...
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https://link.springer.com/article/10.1007/s10439-018-02123-x

Mechanically-enhanced polysaccharide-based scaffolds for tissue engineering of soft tissuesde Souza, R. F. B., de Souza, F. C. B., Rodrigues, C., Drouin, B., Popat, K., Mantovani, D., & Moraes, A. M.Materials Science and Engineering: C. https://doi.org/10.1016/j.msec.2018.09.045

Collagen-based materials are probably among the most used class of biomaterials in tissue engineering and regenerative medicine. Although collagen is often privileged for providing a suitable substrate on which cells can be cultured or a matrix in...
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https://www.sciencedirect.com/science/article/pii/S0928493118302510

Ultra-sensitive microfluidic wearable strain sensor for intraocular pressure monitoringAgaoglu, S., Diep, P., Martini, M., Kt, S., Baday, M., & Araci, I. E.Lab Chip, 2018, DOI: 10.1039/C8LC00758F.

Wearable technologies have potential to transform healthcare by providing continuous measurements of physiological parameters. Sensors that passively monitor physiological pressure without using electronic components are ideal for wearable contact...
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https://pubs.rsc.org/en/content/articlelanding/2018/lc/c8lc00758f#!divAbstract

Composite hydrogel: A high fidelity soft tissue mimic for surgeryTan, Z., Dini, D., Rodriguez y Baena, F., & Forte, A. E.Materials & Design, 160, 886–894. https://doi.org/10.1016/j.matdes.2018.10.018

Accurate tissue phantoms are difficult to design due to the complex non-linear viscoelastic properties of real soft tissues. A composite hydrogel, resulting from a mix of poly(vinyl) alcohol and phytagel, is able to reproduce the viscoelastic...
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https://www.sciencedirect.com/science/article/pii/S0264127518307731

Concurrent Assessment of Cartilage Morphology and Bone Microarchitecture in the Human Knee Using Contrast-Enhanced HR-pQCT ImagingMichalak, G. J., Walker, R., & Boyd, S. K.Journal of Clinical Densitometry, 0(0). https://doi.org/10.1016/j.jocd.2018.07.002

Osteoarthritis (OA) is a prevalent articular disease characterized by whole joint degradation, including a