StemoniX’s microOrgan plates
StemoniX microBrain 3D Assay Ready 96-Well Plates
StemoniX microBrain 3D Assay Ready 384-Well Plates
StemoniX microHeart Assay Ready 96-Well Plate
StemoniX microHeart Assay Ready 384-Well Plate
StemoniX microHeart Cell Ready 96-Well Plate
StemoniX microHeart Cell Ready 384-Well Plate
microBrain 96或384孔板
The power and effectiveness of the microBrain Assay Ready platforms' enhanced network structure and cell maturity are evident through highly synchronized activity. Containing a physiologic mixture of neurons and astrocytes co-matured from a single donor source, cells in the StemoniX microBrain platforms express key markers of cell maturity and a high density of key neural synapses.
microBrain 3D cortical spheroids present quantifiable, robust and uniform spontaneous and synchronized calcium oscillations that can be measured in kinetic high-throughput plate readers (e.g. FLIPR) and high content imaging systems.
microBrain 2D cultures, also high-throughput, are ideal for imaging and infection studies.
microBrain calcium signals can be reproducibly modified with excitatory and inhibitory modulators, confirming the presence of fully functional and integrated glutamatergic/GABAergic circuitry. The StemoniX microBrain platforms demonstrate remarkably consistent performance, making them ideal for high throughput drug discovery, imaging, and screening applications.
Both platforms can be customized to suit your discovery needs.
2D 和 3D 生理相关人类 iPSC 衍生的高通量筛选平台。
microBrain Assay Ready 平台增强的网络结构和细胞成熟度的强大功能和有效性通过高度同步的活动体现出来。 StemoniX microBrain 平台中的细胞含有从单一供体来源共同成熟的神经元和星形胶质细胞的生理混合物，表达细胞成熟的关键标志物和高密度的关键神经突触。
microBrain 3D 皮质球体呈现可量化、稳健且均匀的自发和同步钙振荡，可在动态高通量读板机（例如 FLIPR）和高内涵成像系统中进行测量。
microBrain 2D 培养物也是高通量的，是成像和感染研究的里想选择。
可以使用兴奋性和抑制性调节剂对微脑钙信号进行可重复修改，从而确认存在功能齐quan且集成的谷氨酸能/GABA 能电路。 StemoniX microBrain 平台表现出非常一致的性能，使其成为高通量药物发现、成像和筛选应用的里想选择。
这两个平台都可以定制以满足您的发现需求。
StemoniX® 的科学家通过开发 microBrain® 3D 平台填补了这个缺口。他们使用 hiPSC 源性神经前体细胞，创造了更类似于人类皮质大脑的高同质性 3D 神经皮质细胞球。他们的平台包含成熟的神经元和星形胶质细胞，这些细胞与原代神经培养物类似，对神经调节物具有活性和反应。此外他们将其平台设计为 96 孔和 384 孔样式，用以和高内涵筛选仪器联用，
2、microHeart96或384孔板
用于高通量筛选的结构化心肌细胞
StemoniX microHeart 平台为人类诱导多能干细胞 (iPSC) 衍生的心脏细胞提供结构化环境。
在 microHeart 2.5D 中，细胞被动地排列成紧密代表人类心脏组织的生理相关结构。
在 microHeart 2.5D 板上构建的心脏细胞类似于心脏组织排列，而标准扁平培养器皿导致
随机排列。
在 microHeart 3D 中，心肌细胞被构造成具有均匀、同步跳动的心脏球。
microHeart提供：
增加关键心脏生理基因的表达
增强肌节的组织
与纤维垂直排列的远端插层
收缩的连贯方向性
改善钙处理
microHeart Cell Ready 和 Assay Ready 产品为心脏毒性和心脏安quan性研究、高通量筛选和药物发现提供了里想的模型。可以定制 microHeart 平台以满足您的发现需求。
Structured Cardiomyocytes for High-Throughput Screening
The StemoniX microHeart platform provides a structured environment for human induced pluripotent stem cell (iPSC) derived cardiac cells.
In microHeart 2.5D, cells passively align into a physiologically relevant structure that closely represents human heart tissue.
Cardiac cells structured on microHeart 2.5D plates resemble heart tissue alignment, while standard flat cultureware results in a
random arrangement.
In microHeart 3D, cardiomyocytes are structured into cardiospheres with uniform, synchronized beating.
microHeart provides:
Increased expression of key cardiac physiology genes
Enhanced organization of sarcomeres
Distal intercalated discs aligned perpendicularly to fibers
Coherent directionality of contraction
Improved calcium handling
microHeart Cell Ready and Assay Ready products provide an ideal model for cardiotoxicity and cardiac safety studies, high-throughput screening, and drug discovery. The microHeart platform can be customized to suit your discovery needs.
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